Cryab crystallin, alpha B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cryabprovided by MGI
Official Full Name: crystallin, alpha Bprovided by MGI
Primary source: MGI:MGI:88516
See related: Ensembl:ENSMUSG00000032060 AllianceGenome:MGI:88516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P23; Crya2; HspB5; Crya-2
Summary: This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Biased expression in heart adult (RPKM 661.4), lung adult (RPKM 121.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 27.75 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (50657251..50667936)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (50745951..50756636)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system.
Title: CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system.
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.
Title: Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.
HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage.
Title: HSPB5 suppresses renal inflammation and protects lupus-prone NZB/W F1 mice from severe renal damage.
The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice.
Title: The small heat shock protein HSPB5 attenuates the severity of lupus nephritis in lupus-prone mice.
The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-beta (TGF-beta1)-Smad3/4 signaling.
Title: The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling.
Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
Title: Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
alphaB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy.
Title: αB-Crystallin Alleviates Endotoxin-Induced Retinal Inflammation and Inhibits Microglial Activation and Autophagy.
The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing alphaB-crystallin expression.
Title: The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression.
CRYAB promoted the proliferation and extracellular matrix production of chondrocytes, and inhibited chondrocytes apoptosis and cartilage degradation simultaneously.
Title: αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
CRYAB regulates inflammatory response in intestinal mucosa by inhibiting IKKbeta-mediated signaling.
Title: Small heat shock protein CRYAB inhibits intestinal mucosal inflammatory responses and protects barrier integrity through suppressing IKKβ activity.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cryab (e-PCR), detects polymorphism
- UniSTS:532539

PMC123035P1 (e-PCR)
- UniSTS:270427

Cryab (e-PCR), detects polymorphism
- UniSTS:256365

RH143847 (e-PCR)
- UniSTS:233093

D19440 (e-PCR)
- UniSTS:124814

D9Mit96 (e-PCR), detects polymorphism
- UniSTS:131983

Cryab (e-PCR), detects polymorphism
- UniSTS:499120

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of eye lens	TAS Traceable Author Statement more info	PubMed
enables structural molecule activity	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intracellular transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of programmed cell death	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tubulin complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in I band	ISO Inferred from Sequence Orthology more info
located_in M band	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament bundle	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cardiac myofibril	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in contractile muscle fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-crystallin B chain

Names: alpha(B)-crystallin; crystallin, alpha 2; heat shock protein CryAB; heat shock protein HspB5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289782.1 → NP_001276711.1 alpha-crystallin B chain

See identical proteins and their annotated locations for NP_001276711.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.

Source sequence(s)

AC113987, AC123614

Consensus CDS

CCDS23172.1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Related

ENSMUSP00000149803.2, ENSMUST00000217475.2

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal
NM_001289784.1 → NP_001276713.1 alpha-crystallin B chain

See identical proteins and their annotated locations for NP_001276713.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.

Source sequence(s)

AC123614

Consensus CDS

CCDS23172.1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Related

ENSMUSP00000150669.2, ENSMUST00000216755.2

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal
NM_001289785.1 → NP_001276714.1 alpha-crystallin B chain

See identical proteins and their annotated locations for NP_001276714.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.

Source sequence(s)

AC123614, AK146556

Consensus CDS

CCDS23172.1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Related

ENSMUSP00000149759.2, ENSMUST00000214962.2

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal
NM_009964.3 → NP_034094.1 alpha-crystallin B chain

See identical proteins and their annotated locations for NP_034094.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.

Source sequence(s)

AC123614, AK168999

Consensus CDS

CCDS23172.1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Related

ENSMUSP00000034562.8, ENSMUST00000034562.9

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

50657251..50667936

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244036.1 → XP_030099896.1 alpha-crystallin B chain isoform X1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal
XM_036154592.1 → XP_036010485.1 alpha-crystallin B chain isoform X1

UniProtKB/Swiss-Prot

P23927, Q64325

UniProtKB/TrEMBL

Q52L78

Conserved Domains (2) summary

cd06498
Location:67 → 150

ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...

pfam00525
Location:1 → 52

Crystallin; Alpha crystallin A chain, N terminal