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TMEM150A transmembrane protein 150A [ Homo sapiens (human) ]

Gene ID: 129303, updated on 11-Apr-2024

Summary

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Official Symbol
TMEM150Aprovided by HGNC
Official Full Name
transmembrane protein 150Aprovided by HGNC
Primary source
HGNC:HGNC:24677
See related
Ensembl:ENSG00000168890 MIM:616757; AllianceGenome:HGNC:24677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTN1; TM6P1; TMEM150
Summary
Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 10.3), kidney (RPKM 7.9) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
2p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85598547..85602698, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85600607..85604758, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85825670..85829821, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85811231-85812186 Neighboring gene vesicle associated membrane protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85819815-85820316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85820317-85820816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11705 Neighboring gene ring finger protein 181 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene chromosome 2 open reading frame 68 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85838960-85839341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16134 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:85839517-85839689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16136 Neighboring gene surfactant protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a new gene (rat TM6P1) encoding a fasting-inducible, integral membrane protein with six transmembrane domains. Zhang J, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 10858565
  2. Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function. Hong GS, et al. Neuron, 2016 Jul 6. PMID 27321926
  3. Plasticity of PI4KIIIα interactions at the plasma membrane. Chung J, et al. EMBO Rep, 2015 Mar. PMID 25608530, Free PMC Article
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
  5. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses.
    Title: Overexpression of TMEM150A in glioblastoma multiforme patients correlated with dismal prognoses and compromised immune statuses.
  2. TMEM150A is a functional homologue of Sfk1 in mammalian cells and plays a role in the homeostatic regulation of PI(4,5)P2 at the plasma membrane.
    Title: Plasticity of PI4KIIIα interactions at the plasma membrane.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ90024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 150A
Names
fasting-inducible integral membrane protein TM6P1
tentonin 1
transmembrane protein 150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031738.3 → NP_001026908.1  transmembrane protein 150A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001026908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW009533, BC050466, DA434376
    Consensus CDS
    CCDS33233.1
    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
    Related
    ENSP00000334708.5, ENST00000334462.10
    Conserved Domains (1) summary
    pfam10277
    Location:3 → 229
    Frag1; Frag1/DRAM/Sfk1 family

  2. NM_001369917.1 → NP_001356846.1  transmembrane protein 150A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC016753
    Consensus CDS
    CCDS33233.1
    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
    Related
    ENSP00000387292.1, ENST00000409668.1
    Conserved Domains (1) summary
    pfam10277
    Location:3 → 229
    Frag1; Frag1/DRAM/Sfk1 family

  3. NM_153342.4 → NP_699173.2  transmembrane protein 150A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016753
    Consensus CDS
    CCDS1982.1
    Related
    ENSP00000302715.3, ENST00000306353.7
    Conserved Domains (1) summary
    pfam10277
    Location:37 → 176
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85598547..85602698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711931.4 → XP_006711994.1  transmembrane protein 150A isoform X1

    See identical proteins and their annotated locations for XP_006711994.1

    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
    Conserved Domains (1) summary
    pfam10277
    Location:3 → 229
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_047443258.1 → XP_047299214.1  transmembrane protein 150A isoform X4

  3. XM_006711930.4 → XP_006711993.1  transmembrane protein 150A isoform X1

    See identical proteins and their annotated locations for XP_006711993.1

    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6
    Conserved Domains (1) summary
    pfam10277
    Location:3 → 229
    Frag1; Frag1/DRAM/Sfk1 family

  4. XM_011532508.3 → XP_011530810.1  transmembrane protein 150A isoform X4

    See identical proteins and their annotated locations for XP_011530810.1

    UniProtKB/Swiss-Prot
    Q86TG1
    Conserved Domains (1) summary
    pfam10277
    Location:37 → 176
    Frag1; Frag1/DRAM/Sfk1 family

  5. XM_011532505.3 → XP_011530807.1  transmembrane protein 150A isoform X2

    Conserved Domains (1) summary
    pfam10277
    Location:1 → 205
    Frag1; Frag1/DRAM/Sfk1 family

  6. XM_047443265.1 → XP_047299221.1  transmembrane protein 150A isoform X5

  7. XM_011532507.3 → XP_011530809.1  transmembrane protein 150A isoform X3

    See identical proteins and their annotated locations for XP_011530809.1

    Conserved Domains (1) summary
    pfam10277
    Location:20 → 182
    Frag1; Frag1/DRAM/Sfk1 family

  8. XM_017003305.2 → XP_016858794.1  transmembrane protein 150A isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:20 → 182
    Frag1; Frag1/DRAM/Sfk1 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85600607..85604758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340463.1 → XP_054196438.1  transmembrane protein 150A isoform X1

    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6

  2. XM_054340468.1 → XP_054196443.1  transmembrane protein 150A isoform X4

  3. XM_054340464.1 → XP_054196439.1  transmembrane protein 150A isoform X1

    UniProtKB/Swiss-Prot
    A8K764, B7WPQ9, D6W5L2, Q86TG1, Q8N2R6

  4. XM_054340469.1 → XP_054196444.1  transmembrane protein 150A isoform X4

  5. XM_054340465.1 → XP_054196440.1  transmembrane protein 150A isoform X2

  6. XM_054340470.1 → XP_054196445.1  transmembrane protein 150A isoform X5

  7. XM_054340467.1 → XP_054196442.1  transmembrane protein 150A isoform X3

  8. XM_054340466.1 → XP_054196441.1  transmembrane protein 150A isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86TG1.1 GenPept UniProtKB/Swiss-Prot:Q86TG1

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