Crhbp corticotropin releasing hormone binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crhbpprovided by MGI
Official Full Name: corticotropin releasing hormone binding proteinprovided by MGI
Primary source: MGI:MGI:88497
See related: Ensembl:ENSMUSG00000021680 AllianceGenome:MGI:88497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRH-BP
Summary: Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and maternal aggressive behavior. Acts upstream of or within hormone metabolic process. Located in extracellular space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in mental depression. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 5.5), cortex adult (RPKM 5.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 49.5 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (95567884..95581339, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (95431376..95444831, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sex differences in CRF1, CRF, and CRFBP expression in C57BL/6J mouse brain across the lifespan and in response to acute stress.
Title: Sex differences in CRF1, CRF, and CRFBP expression in C57BL/6J mouse brain across the lifespan and in response to acute stress.
Repeated cycles of binge drinking alter CRF-BP mRNA expression in the medial prefrontal cortex.
Title: Binge Drinking Decreases Corticotropin-Releasing Factor-Binding Protein Expression in the Medial Prefrontal Cortex of Mice.
Ventral tegmental area CRH-BP is involved in the initial stages of escalated ethanol drinking.
Title: Corticotropin Releasing Factor Binding Protein and CRF2 Receptors in the Ventral Tegmental Area: Modulation of Ethanol Binge Drinking in C57BL/6J Mice.
These studies demonstrate a role for the pituitary CRH-BP in attenuating the HPA response to stress in female mice.
Title: Pituitary CRH-binding protein and stress in female mice.
Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.
Title: Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression.
analysis of regulation and function of CRH-BP [review]
Title: CRH-BP: the regulation and function of a phylogenetically conserved binding protein.
estrogen-regulated expression of corticotropin-releasing hormone-binding protein in lactotropes in female mice suggests that the pituitary is an important site for interactions between the hypothalamic-pituitary-adrenal axis and other endocrine systems
Title: Sexually dimorphic expression of corticotropin-releasing hormone-binding protein in the mouse pituitary.
GnRH induces a 3.7-fold increase in CRH-BP mRNA levels via multiple intracellular signaling pathways and a multipartite GnRH response element.
Title: Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alphaT3-1 cells.
Evidence is presented suggesting that the CRH-BP may be required for corticotropin-releasing factor-induced potentiation of NMDA receptors in dopaminergic neurons of the ventral tegmental area.
Title: Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gonadotropin-releasing hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to immobilization stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in maternal aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of corticotropin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of corticotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, dopaminergic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in secondary lysosome	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: corticotropin-releasing factor-binding protein

Names: CRF-BP; CRF-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.