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Crem cAMP responsive element modulator [ Mus musculus (house mouse) ]

Gene ID: 12916, updated on 16-Apr-2024

Summary

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Official Symbol
Cremprovided by MGI
Official Full Name
cAMP responsive element modulatorprovided by MGI
Primary source
MGI:MGI:88495
See related
Ensembl:ENSMUSG00000063889 AllianceGenome:MGI:88495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ICER; ICERI
Summary
This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]
Expression
Biased expression in testis adult (RPKM 21.9), liver adult (RPKM 1.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Crem in Genome Data Viewer
Location:
18 A1; 18 2.14 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (3263181..3337688, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (3266354..3337773, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, pseudogene 152 Neighboring gene STARR-seq mESC enhancer starr_43652 Neighboring gene STARR-seq mESC enhancer starr_43653 Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene STARR-seq mESC enhancer starr_43654 Neighboring gene STARR-seq mESC enhancer starr_43655 Neighboring gene STARR-positive B cell enhancer ABC_E5646 Neighboring gene predicted gene 6225 Neighboring gene cullin 2 Neighboring gene profilin 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. Seidl MD, et al. FASEB J, 2020 Aug. PMID 32602979
  2. Novel insights into biological roles of inducible cAMP early repressor ICER. Režen T, et al. Biochem Biophys Res Commun, 2020 Sep 17. PMID 32534736
  3. Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia. Barbati SA, et al. Endocrinology, 2017 Jul 1. PMID 28368536
  4. The transcriptional repressor ICER binds to multiple loci throughout the genome. Muñiz LC, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27590584, Free PMC Article
  5. Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice. Seidl MD, et al. Pflugers Arch, 2015 Oct. PMID 25425331, Free PMC Article

See all (157) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
    Title: Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
  2. Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation.
    Title: Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation.
  3. Novel insights into biological roles of inducible cAMP early repressor ICER.
    Title: Novel insights into biological roles of inducible cAMP early repressor ICER.
  4. CREM-/- mice were more susceptible to E. histolytica amebic colitis
    Title: Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease.
  5. Studied role and importance of inducible cAMP early repressor (ICER) in glutaminolysis and the generation of Th17 cells. Demonstrated the IL-17 promoting ICER works through the direct control of glutaminase 1 (Gls1) by binding its promoter.
    Title: Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.
  6. Deficiency in ICER elevated binding of NF-kappaB to promoters of pro-inflammatory genes and their subsequent gene expression. Mice deficient in ICER were hypersensitive to LPS-induced endotoxic shock and showed propagated inflammation.
    Title: A negative feedback loop of ICER and NF-κB regulates TLR signaling in innate immune responses.
  7. The transcription factor CREM was found to be important in the regulation of cardiotoxicity-associated genes.
    Title: Transcription Factor CREM Mediates High Glucose Response in Cardiomyocytes and in a Male Mouse Model of Prolonged Hyperglycemia.
  8. Our results demonstrate that overexpression of CREMalpha in T cells changes the inflammatory milieu, attenuating initiation and progression of CLD.
    Title: Hepatic overexpression of cAMP-responsive element modulator α induces a regulatory T-cell response in a murine model of chronic liver disease.
  9. the role of ICER in ovarian function, was investigated.
    Title: The transcriptional repressor ICER binds to multiple loci throughout the genome.
  10. Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117.
    Title: Phosphorylated testis-specific serine/threonine kinase 4 may phosphorylate Crem at Ser-117.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within glycosphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cAMP IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cAMP-responsive element modulator
Names
cAMP responsive element moderator
inducible cAMP early repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110850.2 → NP_001104320.1  cAMP-responsive element modulator isoform 4

    See identical proteins and their annotated locations for NP_001104320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as alpha gamma) lacks three alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AY738716, BP770366, BQ556287
    UniProtKB/TrEMBL
    F6U9F5
    Related
    ENSMUSP00000115336.2, ENSMUST00000137568.8
    Conserved Domains (2) summary
    cd14690
    Location:177 → 231
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  2. NM_001110851.1 → NP_001104321.1  cAMP-responsive element modulator isoform 7

    See identical proteins and their annotated locations for NP_001104321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains multiple differences in the UTRs and coding region, including a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) contains a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AK009841, AK010806, AK161366
    Consensus CDS
    CCDS50213.1
    UniProtKB/TrEMBL
    Q3TTH6
    Related
    ENSMUSP00000122282.2, ENSMUST00000142690.2
    Conserved Domains (1) summary
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  3. NM_001110852.1 → NP_001104322.1  cAMP-responsive element modulator isoform 8

    See identical proteins and their annotated locations for NP_001104322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains multiple differences in the UTRs and coding region, including a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (8) contains a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AK010806
    Consensus CDS
    CCDS50212.1
    UniProtKB/TrEMBL
    Q9CQ87
    Related
    ENSMUSP00000121210.2, ENSMUST00000149803.8
    Conserved Domains (1) summary
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  4. NM_001110853.2 → NP_001104323.1  cAMP-responsive element modulator isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5'UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (9) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK015641, AK076797, BP770366, BQ556287
    Consensus CDS
    CCDS50211.1
    UniProtKB/TrEMBL
    E9PV35, F6XRJ7
    Related
    ENSMUSP00000121118.2, ENSMUST00000122958.8
    Conserved Domains (2) summary
    cd14690
    Location:248 → 302
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:59 → 98
    pKID; pKID domain

  5. NM_001110854.1 → NP_001104324.2  cAMP-responsive element modulator isoform 10

    See identical proteins and their annotated locations for NP_001104324.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains multiple differences in the UTRs and coding region, including lacking multiple exons, compared to variant 1. It represents use of an alternate promoter and contains an alternate 5' coding region. The encoded isoform (10) is shorter and has distinct N- and C- termini, compared to isoform 1.
    Source sequence(s)
    AJ311667, AY738716, BE689077, BP770366, BQ556287
    Consensus CDS
    CCDS50210.2
    UniProtKB/TrEMBL
    F6QWT6, Q78Z98
    Related
    ENSMUSP00000119194.3, ENSMUST00000154705.8
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  6. NM_001110855.1 → NP_001104325.2  cAMP-responsive element modulator isoform 11

    See identical proteins and their annotated locations for NP_001104325.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains multiple differences in the UTRs and coding region, including lacking multiple exons, compared to variant 1. It represents use of an alternate promoter and contains an alternate 5' coding region. The encoded isoform (11) is shorter and has distinct N- and C- termini, compared to isoform 1.
    Source sequence(s)
    AJ292222, AY738716, BE689077, BP770366, BQ556287
    Consensus CDS
    CCDS50209.2
    UniProtKB/TrEMBL
    F6VJ22, Q78Z98
    Related
    ENSMUSP00000118578.3, ENSMUST00000151084.8
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  7. NM_001110856.2 → NP_001104326.1  cAMP-responsive element modulator isoform 2

    See identical proteins and their annotated locations for NP_001104326.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as epsilon or tau 1 alpha) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AY738718, BP770366, BQ556287
    Consensus CDS
    CCDS50214.1
    UniProtKB/TrEMBL
    F6Q346
    Related
    ENSMUSP00000119353.2, ENSMUST00000131899.8
    Conserved Domains (2) summary
    cd14690
    Location:238 → 292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  8. NM_001110857.2 → NP_001104327.1  cAMP-responsive element modulator isoform 5

    See identical proteins and their annotated locations for NP_001104327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as beta) lacks two alternate in-frame exons, compared to variant 1. The structure of this variant is characterized in PMID: 1847666. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC117589
    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:189 → 243
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  9. NM_001110858.2 → NP_001104328.1  cAMP-responsive element modulator isoform 6

    See identical proteins and their annotated locations for NP_001104328.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as gamma) lacks three alternate in-frame exons, compared to variant 1. The structure of this variant is characterized in PMID: 1847666. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC117589
    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:177 → 231
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  10. NM_001110859.2 → NP_001104329.1  cAMP-responsive element modulator isoform 1

    See identical proteins and their annotated locations for NP_001104329.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as tau) encodes the longest isoform (1). The structure of this variant is described in PMID: 1370576.
    Source sequence(s)
    AC117589
    Consensus CDS
    CCDS50215.1
    UniProtKB/Swiss-Prot
    P27698, P27699, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
    UniProtKB/TrEMBL
    F6XRJ7
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  11. NM_001271503.1 → NP_001258432.1  cAMP-responsive element modulator isoform 12

    See identical proteins and their annotated locations for NP_001258432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as tau 1 gamma) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (12) is shorter than isoform 1.
    Source sequence(s)
    AC117589, AY738715
    UniProtKB/TrEMBL
    F6RB97
    Related
    ENSMUSP00000119638.2, ENSMUST00000146265.8
    Conserved Domains (2) summary
    cd14690
    Location:226 → 280
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  12. NM_001271504.1 → NP_001258433.1  cAMP-responsive element modulator isoform 13

    See identical proteins and their annotated locations for NP_001258433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as tau 1 alpha gamma) lacks two alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (13) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AY738717
    Consensus CDS
    CCDS70863.1
    UniProtKB/TrEMBL
    F6Q346
    Conserved Domains (2) summary
    cd14690
    Location:226 → 280
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  13. NM_001271505.1 → NP_001258434.1  cAMP-responsive element modulator isoform 14

    See identical proteins and their annotated locations for NP_001258434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14, also known as tau 2 alpha) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (14) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AY738719
    Consensus CDS
    CCDS70862.1
    UniProtKB/TrEMBL
    F6W4F5
    Related
    ENSMUSP00000123515.2, ENSMUST00000152900.8
    Conserved Domains (2) summary
    cd14690
    Location:252 → 306
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  14. NM_001271506.1 → NP_001258435.1  cAMP-responsive element modulator isoform 15

    See identical proteins and their annotated locations for NP_001258435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as tau alpha gamma) lacks an alternate in-frame exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589, AY738721
    Consensus CDS
    CCDS70864.1
    UniProtKB/TrEMBL
    F6QKL8
    Related
    ENSMUSP00000121541.2, ENSMUST00000130455.8
    Conserved Domains (2) summary
    cd14690
    Location:289 → 343
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  15. NM_001311066.1 → NP_001297995.1  cAMP-responsive element modulator isoform 16

    See identical proteins and their annotated locations for NP_001297995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks part of the 5' coding region, uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (16) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC117589, AK076797, BP770366, BP771675, CX217456
    Consensus CDS
    CCDS79584.1
    UniProtKB/TrEMBL
    D3Z326, Q78Z98
    Related
    ENSMUSP00000121352.2, ENSMUST00000124747.8
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  16. NM_001311067.1 → NP_001297996.1  cAMP-responsive element modulator isoform 17

    See identical proteins and their annotated locations for NP_001297996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks part of the 5' coding region, uses an alternate 5'-terminal exon and an alternate start codon, compared to variant 1. The encoded isoform (17) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC117589
    Consensus CDS
    CCDS79585.1
    UniProtKB/TrEMBL
    D3Z6A5, Q78Z98
    Related
    ENSMUSP00000061925.7, ENSMUST00000049942.13
    Conserved Domains (1) summary
    cd14690
    Location:63 → 117
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  17. NM_001374833.1 → NP_001361762.1  cAMP-responsive element modulator isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC117589
    Consensus CDS
    CCDS89179.1
    UniProtKB/TrEMBL
    D3Z2U7, F6QKL8
    Related
    ENSMUSP00000121388.2, ENSMUST00000156234.8
    Conserved Domains (2) summary
    cd14690
    Location:285 → 339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  18. NM_013498.3 → NP_038526.2  cAMP-responsive element modulator isoform 3

    See identical proteins and their annotated locations for NP_038526.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as alpha) lacks two alternate in-frame exons and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117589
    Consensus CDS
    CCDS29031.2
    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:189 → 243
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

RNA

  1. NR_073193.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) contains multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC117589, AY738720

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    3263181..3337688 complement
    Download
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mRNA and Protein(s)

  1. XM_006525570.3 → XP_006525633.1  cAMP-responsive element modulator isoform X23

    UniProtKB/TrEMBL
    D3Z011, D3Z0R0
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  2. XM_030250301.2 → XP_030106161.1  cAMP-responsive element modulator isoform X9

    UniProtKB/TrEMBL
    D3Z0R0
    Conserved Domains (2) summary
    cd14690
    Location:261 → 315
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:84 → 123
    pKID; pKID domain

  3. XM_030250300.2 → XP_030106160.1  cAMP-responsive element modulator isoform X7

    UniProtKB/TrEMBL
    D3Z0R0
    Conserved Domains (2) summary
    cd14690
    Location:273 → 327
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:84 → 123
    pKID; pKID domain

  4. XM_030250303.2 → XP_030106163.1  cAMP-responsive element modulator isoform X18

    UniProtKB/TrEMBL
    F6XRJ7
    Conserved Domains (2) summary
    cd14690
    Location:236 → 290
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:59 → 98
    pKID; pKID domain

  5. XM_006525579.4 → XP_006525642.1  cAMP-responsive element modulator isoform X39

    See identical proteins and their annotated locations for XP_006525642.1

    UniProtKB/TrEMBL
    D3YVP3
    Related
    ENSMUSP00000114280.2, ENSMUST00000147138.8
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  6. XM_006525580.4 → XP_006525643.1  cAMP-responsive element modulator isoform X40

    See identical proteins and their annotated locations for XP_006525643.1

    UniProtKB/TrEMBL
    D3YVP3
    Related
    ENSMUSP00000115423.2, ENSMUST00000140332.8
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  7. XM_030250313.2 → XP_030106173.1  cAMP-responsive element modulator isoform X41

    UniProtKB/TrEMBL
    D3YVP3
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  8. XM_030250306.2 → XP_030106166.1  cAMP-responsive element modulator isoform X27

    UniProtKB/TrEMBL
    F6RB97
    Conserved Domains (2) summary
    cd14690
    Location:222 → 276
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  9. XM_036160962.1 → XP_036016855.1  cAMP-responsive element modulator isoform X19

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:236 → 290
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  10. XM_036160968.1 → XP_036016861.1  cAMP-responsive element modulator isoform X37

    UniProtKB/TrEMBL
    A0A0R4J1V7, F6U9F5
    Related
    ENSMUSP00000120557.2, ENSMUST00000123672.8
    Conserved Domains (2) summary
    cd14690
    Location:161 → 215
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  11. XM_036160959.1 → XP_036016852.1  cAMP-responsive element modulator isoform X5

    UniProtKB/TrEMBL
    F6XRJ7
    Conserved Domains (2) summary
    cd14690
    Location:285 → 339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  12. XM_006525565.5 → XP_006525628.1  cAMP-responsive element modulator isoform X15

    See identical proteins and their annotated locations for XP_006525628.1

    UniProtKB/TrEMBL
    F6Q346
    Related
    ENSMUSP00000127353.2, ENSMUST00000165086.8
    Conserved Domains (2) summary
    cd14690
    Location:238 → 292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  13. XM_036160966.1 → XP_036016859.1  cAMP-responsive element modulator isoform X26

    UniProtKB/TrEMBL
    F6Q346
    Conserved Domains (2) summary
    cd14690
    Location:222 → 276
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  14. XM_030250309.2 → XP_030106169.1  cAMP-responsive element modulator isoform X34

    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:173 → 227
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  15. XM_030250308.1 → XP_030106168.1  cAMP-responsive element modulator isoform X28

    UniProtKB/TrEMBL
    F6Q346
    Conserved Domains (2) summary
    cd14690
    Location:210 → 264
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  16. XM_036160967.1 → XP_036016860.1  cAMP-responsive element modulator isoform X29

    UniProtKB/TrEMBL
    F6RB97
    Conserved Domains (2) summary
    cd14690
    Location:210 → 264
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  17. XM_036160960.1 → XP_036016853.1  cAMP-responsive element modulator isoform X8

    UniProtKB/TrEMBL
    F6QKL8
    Conserved Domains (2) summary
    cd14690
    Location:273 → 327
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  18. XM_006525561.5 → XP_006525624.1  cAMP-responsive element modulator isoform X10

    See identical proteins and their annotated locations for XP_006525624.1

    UniProtKB/TrEMBL
    F6W4F5
    Related
    ENSMUSP00000080780.6, ENSMUST00000082141.12
    Conserved Domains (2) summary
    cd14690
    Location:252 → 306
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  19. XM_030250311.1 → XP_030106171.1  cAMP-responsive element modulator isoform X36

    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:161 → 215
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  20. XM_030250305.1 → XP_030106165.1  cAMP-responsive element modulator isoform X24

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  21. XM_036160965.1 → XP_036016858.1  cAMP-responsive element modulator isoform X25

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  22. XM_006525566.5 → XP_006525629.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:236 → 290
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  23. XM_036160969.1 → XP_036016862.1  cAMP-responsive element modulator isoform X38

    UniProtKB/TrEMBL
    D3Z773
    Conserved Domains (2) summary
    cd14690
    Location:149 → 203
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  24. XM_030250310.2 → XP_030106170.1  cAMP-responsive element modulator isoform X35

    UniProtKB/TrEMBL
    A0A0R4J1S0, F6U9F5
    Related
    ENSMUSP00000115471.2, ENSMUST00000130599.8
    Conserved Domains (2) summary
    cd14690
    Location:173 → 227
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  25. XM_030250302.1 → XP_030106162.1  cAMP-responsive element modulator isoform X11

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:252 → 306
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  26. XM_036160964.1 → XP_036016857.1  cAMP-responsive element modulator isoform X23

    UniProtKB/TrEMBL
    D3Z011, D3Z0R0
    Related
    ENSMUSP00000120349.2, ENSMUST00000144496.8
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  27. XM_036160963.1 → XP_036016856.1  cAMP-responsive element modulator isoform X22

    UniProtKB/TrEMBL
    D3Z0R0
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  28. XM_006525576.4 → XP_006525639.1  cAMP-responsive element modulator isoform X33

    See identical proteins and their annotated locations for XP_006525639.1

    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:177 → 231
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  29. XM_006525575.4 → XP_006525638.1  cAMP-responsive element modulator isoform X32

    See identical proteins and their annotated locations for XP_006525638.1

    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:177 → 231
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  30. XM_006525574.4 → XP_006525637.1  cAMP-responsive element modulator isoform X31

    See identical proteins and their annotated locations for XP_006525637.1

    UniProtKB/TrEMBL
    F6U9F5
    Conserved Domains (2) summary
    cd14690
    Location:189 → 243
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  31. XM_006525573.4 → XP_006525636.1  cAMP-responsive element modulator isoform X30

    See identical proteins and their annotated locations for XP_006525636.1

    UniProtKB/TrEMBL
    F6U9F5
    Related
    ENSMUSP00000122051.2, ENSMUST00000154135.8
    Conserved Domains (2) summary
    cd14690
    Location:189 → 243
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  32. XM_006525564.4 → XP_006525627.1  cAMP-responsive element modulator isoform X14

    UniProtKB/TrEMBL
    D3YXV5, F6W4F5
    Related
    ENSMUSP00000118267.2, ENSMUST00000151311.8
    Conserved Domains (2) summary
    cd14690
    Location:240 → 294
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  33. XM_006525563.4 → XP_006525626.1  cAMP-responsive element modulator isoform X13

    UniProtKB/TrEMBL
    F6W4F5
    Conserved Domains (2) summary
    cd14690
    Location:240 → 294
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:63 → 102
    pKID; pKID domain

  34. XM_006525567.4 → XP_006525630.1  cAMP-responsive element modulator isoform X20

    See identical proteins and their annotated locations for XP_006525630.1

    UniProtKB/TrEMBL
    F6Q346
    Related
    ENSMUSP00000118128.2, ENSMUST00000154470.8
    Conserved Domains (2) summary
    cd14690
    Location:226 → 280
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  35. XM_017317808.2 → XP_017173297.1  cAMP-responsive element modulator isoform X16

    UniProtKB/TrEMBL
    F6RB97
    Conserved Domains (2) summary
    cd14690
    Location:238 → 292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  36. XM_006525557.4 → XP_006525620.1  cAMP-responsive element modulator isoform X4

    UniProtKB/TrEMBL
    F6XRJ7
    Related
    ENSMUSP00000118649.2, ENSMUST00000127601.8
    Conserved Domains (2) summary
    cd14690
    Location:289 → 343
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  37. XM_006525556.4 → XP_006525619.1  cAMP-responsive element modulator isoform X3

    See identical proteins and their annotated locations for XP_006525619.1

    UniProtKB/TrEMBL
    F6QKL8
    Related
    ENSMUSP00000025069.5, ENSMUST00000025069.11
    Conserved Domains (2) summary
    cd14690
    Location:289 → 343
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  38. XM_006525554.4 → XP_006525617.1  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_006525617.1

    UniProtKB/TrEMBL
    F6QKL8
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  39. XM_011246820.4 → XP_011245122.1  cAMP-responsive element modulator isoform X1

    See identical proteins and their annotated locations for XP_011245122.1

    UniProtKB/TrEMBL
    F6QKL8
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  40. XM_006525559.2 → XP_006525622.1  cAMP-responsive element modulator isoform X6

    See identical proteins and their annotated locations for XP_006525622.1

    UniProtKB/TrEMBL
    D3Z7M6, F6QKL8
    Conserved Domains (2) summary
    cd14690
    Location:273 → 327
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:84 → 123
    pKID; pKID domain

  41. XM_006525560.1 → XP_006525623.1  cAMP-responsive element modulator isoform X6

    See identical proteins and their annotated locations for XP_006525623.1

    UniProtKB/TrEMBL
    D3Z7M6, F6QKL8
    Related
    ENSMUSP00000122179.2, ENSMUST00000154715.8
    Conserved Domains (2) summary
    cd14690
    Location:273 → 327
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:84 → 123
    pKID; pKID domain

  42. XM_006525562.5 → XP_006525625.1  cAMP-responsive element modulator isoform X12

    See identical proteins and their annotated locations for XP_006525625.1

    UniProtKB/TrEMBL
    E9PWV9, F6QKL8
    Related
    ENSMUSP00000114780.2, ENSMUST00000126578.8
    Conserved Domains (2) summary
    cd14690
    Location:248 → 302
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:59 → 98
    pKID; pKID domain

  43. XM_030250315.2 → XP_030106175.1  cAMP-responsive element modulator isoform X42

    UniProtKB/TrEMBL
    D3Z7P7, Q78Z98
    Related
    ENSMUSP00000122123.2, ENSMUST00000139537.2
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  44. XM_006525555.5 → XP_006525618.1  cAMP-responsive element modulator isoform X2

    See identical proteins and their annotated locations for XP_006525618.1

    UniProtKB/Swiss-Prot
    P27698, P27699, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
    UniProtKB/TrEMBL
    F6XRJ7
    Related
    ENSMUSP00000121233.2, ENSMUST00000150235.8
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  45. XM_006525568.5 → XP_006525631.1  cAMP-responsive element modulator isoform X21

    See identical proteins and their annotated locations for XP_006525631.1

    UniProtKB/TrEMBL
    F6RB97
    Conserved Domains (2) summary
    cd14690
    Location:226 → 280
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27699.2 GenPept UniProtKB/Swiss-Prot:P27699

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