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Crabp1 cellular retinoic acid binding protein I [ Mus musculus (house mouse) ]

Gene ID: 12903, updated on 5-Mar-2024

Summary

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Official Symbol
Crabp1provided by MGI
Official Full Name
cellular retinoic acid binding protein Iprovided by MGI
Primary source
MGI:MGI:88490
See related
Ensembl:ENSMUSG00000032291 AllianceGenome:MGI:88490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbp-5; CrabpI; CRABP-I; Crabp-1
Summary
Predicted to enable fatty acid binding activity and retinoic acid binding activity. Predicted to be involved in fatty acid transport. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human CRABP1 (cellular retinoic acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 232.5), limb E14.5 (RPKM 196.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 29.76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54672032..54680394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54764748..54773110)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member A4 Neighboring gene microRNA 5710 Neighboring gene STARR-positive B cell enhancer ABC_E3830 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene STARR-seq mESC enhancer starr_24173 Neighboring gene STARR-seq mESC enhancer starr_24174 Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24177 Neighboring gene STARR-seq mESC enhancer starr_24179 Neighboring gene STARR-positive B cell enhancer ABC_E2292 Neighboring gene iron responsive element binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration. Nhieu J, et al. Int J Mol Sci, 2023 Mar 4. PMID 36902410, Free PMC Article
  2. Modulation of adipose inflammation by cellular retinoic acid-binding protein 1. Wei CW, et al. Int J Obes (Lond), 2022 Oct. PMID 35794192, Free PMC Article
  3. Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression. Lin YL, et al. Int J Mol Sci, 2021 Nov 12. PMID 34830120, Free PMC Article
  4. A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Park SW, et al. Sci Rep, 2019 Jul 29. PMID 31358819, Free PMC Article
  5. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy. Lin YW, et al. Int J Obes (Lond), 2020 Feb. PMID 31164723, Free PMC Article

See all (248) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration.
    Title: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration.
  2. Modulation of adipose inflammation by cellular retinoic acid-binding protein 1.
    Title: Modulation of adipose inflammation by cellular retinoic acid-binding protein 1.
  3. Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
    Title: Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.
  4. Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.
    Title: Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression.
  5. Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases.
    Title: Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases.
  6. Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy.
    Title: Cellular retinoic acid binding protein 1 protects mice from high-fat diet-induced obesity by decreasing adipocyte hypertrophy.
  7. A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1.
    Title: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1.
  8. These are supported by the fact that CRABP1 gene knockout (KO) mice exhibit multiple phenotypes including hippocampal NSC expansion and spontaneous cardiac hypertrophy. This indicates that more potential processes/signaling pathways involving atRA-CRABP1 may exist, which remain to be identified.
    Title: All-trans Retinoic Acid as a Versatile Cytosolic Signal Modulator Mediated by CRABP1.
  9. This is the first report of a physiological role of cellular retinoic acid binding protein I( CRABP)1 as an endogenous regulator of calcium-calmodulin protein kinase II, which protects the heart from isoproterenol-induced damage.
    Title: CRABP1 protects the heart from isoproterenol-induced acute and chronic remodeling.
  10. The physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory.
    Title: Cellular Retinoic Acid-Binding Protein 1 Modulates Stem Cell Proliferation to Affect Learning and Memory in Male Mice.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables retinal binding IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables retinoid binding TAS
Traceable Author Statement
more info
 PubMed 
enables retinol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cellular retinoic acid-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284507.1 → NP_001271436.1  cellular retinoic acid-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001271436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC159892
    Conserved Domains (1) summary
    cl10502
    Location:2 → 99
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. NM_013496.3 → NP_038524.1  cellular retinoic acid-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159892, AK144397, CD742428
    Consensus CDS
    CCDS23195.1
    UniProtKB/Swiss-Prot
    P62965, Q3UN78
    Related
    ENSMUSP00000034830.9, ENSMUST00000034830.9
    Conserved Domains (1) summary
    cd19460
    Location:2 → 137
    CRABP1; cellular retinoic acid-binding protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54672032..54680394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62965.2 GenPept UniProtKB/Swiss-Prot:P62965

Gene LinkOut

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