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Cpd carboxypeptidase D [ Mus musculus (house mouse) ]

Gene ID: 12874, updated on 11-Apr-2024

Summary

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Official Symbol
Cpdprovided by MGI
Official Full Name
carboxypeptidase Dprovided by MGI
Primary source
MGI:MGI:107265
See related
Ensembl:ENSMUSG00000020841 AllianceGenome:MGI:107265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D830034L15Rik
Summary
Predicted to enable metallocarboxypeptidase activity and protein phosphatase 2A binding activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be located in nucleus; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CPD (carboxypeptidase D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 23.5), ovary adult (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.05 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76668034..76737834, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76777208..76847008, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene trafficking regulator of GLUT4 (SLC2A4) 1 Neighboring gene STARR-positive B cell enhancer ABC_E9829 Neighboring gene golgi SNAP receptor complex member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3977 Neighboring gene STARR-seq mESC enhancer starr_30045 Neighboring gene predicted gene, 53688 Neighboring gene predicted gene, 40200 Neighboring gene transmembrane and immunoglobulin domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking. Kalinina E, et al. J Cell Biochem, 2002. PMID 11891854
  2. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Lu Y, et al. Hepatology, 2006 Jul. PMID 16799984
  3. Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking. Kalinina EV, et al. J Biol Chem, 2003 Mar 14. PMID 12643288
  4. Cloning, functional expression, and chromosomal localization of the human and mouse gp180-carboxypeptidase D-like enzyme. Ishikawa T, et al. Gene, 1998 Jul 30. PMID 9714835
  5. Cloning and sequence analysis of cDNA encoding rat carboxypeptidase D. Xin X, et al. DNA Cell Biol, 1997 Jul. PMID 9260933

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Palmitoylation of carboxypeptidase D has a role in intracellular trafficking
    Title: Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.
  2. CPD localization to the TGN requires both static retention involving the C-terminal domain and phosphorylation at a CK2 site, which regulates the binding of adaptor proteins.
    Title: Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking.
  3. The isolation and characterization of CPD from several haematopoietic tumour cells are reported.
    Title: Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carboxypeptidase D
Names
gp180
metallocarboxypeptidase D
NP_031780.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007754.2 → NP_031780.2  carboxypeptidase D precursor

    See identical proteins and their annotated locations for NP_031780.2

    Status: VALIDATED

    Source sequence(s)
    AK137737, AL645479, CJ130378
    Consensus CDS
    CCDS25071.1
    UniProtKB/Swiss-Prot
    O89001, Q5SVH8
    Related
    ENSMUSP00000021201.6, ENSMUST00000021201.6
    Conserved Domains (4) summary
    cd03863
    Location:495 → 790
    M14_CPD_II; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain II subgroup
    cd03868
    Location:86 → 378
    M14_CPD_I; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase D, domain I subgroup
    cd11308
    Location:794 → 869
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cl11393
    Location:929 → 1207
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76668034..76737834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89001.2 GenPept UniProtKB/Swiss-Prot:O89001

Gene LinkOut

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