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Cox4i1 cytochrome c oxidase subunit 4I1 [ Mus musculus (house mouse) ]

Gene ID: 12857, updated on 11-Apr-2024

Summary

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Official Symbol
Cox4i1provided by MGI
Official Full Name
cytochrome c oxidase subunit 4I1provided by MGI
Primary source
MGI:MGI:88473
See related
Ensembl:ENSMUSG00000031818 AllianceGenome:MGI:88473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX; Cox4; IV-1; COXIV; Cox4a; COX IV-1
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 1297.8), kidney adult (RPKM 1026.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 69.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121394964..121400948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120668225..120674209)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene, 27021 Neighboring gene STARR-seq mESC enhancer starr_22909 Neighboring gene predicted gene, 33075 Neighboring gene ER membrane protein complex subunit 8 Neighboring gene predicted gene, 39265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:123225678-123225981 Neighboring gene STARR-positive B cell enhancer ABC_E6694 Neighboring gene mitochondrial ribosomal protein L30 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The effect of treadmill training and N-acetyl-l-cysteine intervention on biogenesis of cytochrome c oxidase (COX). Sun Y, et al. Free Radic Biol Med, 2015 Oct. PMID 26159509
  2. Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model. Binder NK, et al. Mol Hum Reprod, 2015 May. PMID 25731709
  3. Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. Sundar Boyalla S, et al. J Neurosci Res, 2011 Dec. PMID 21598289
  4. Decreased cytochrome c oxidase IV expression reduces steroidogenesis. Pawlak KJ, et al. J Pharmacol Exp Ther, 2011 Aug. PMID 21558439, Free PMC Article
  5. New isoforms of cytochrome c oxidase subunit IV in tuna fish. Hüttemann M. Biochim Biophys Acta, 2000 Jun 21. PMID 11004496

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Destabilizing COXIV in Muller Glia Increases Retinal Glycolysis and Alters Scotopic Electroretinogram.
    Title: Destabilizing COXIV in Müller Glia Increases Retinal Glycolysis and Alters Scotopic Electroretinogram.
  2. MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1.
    Title: MicroRNA-338 inhibition protects against focal cerebral ischemia and preserves mitochondrial function in vitro in astrocytes and neurons via COX4I1.
  3. DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
    Title: DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation.
  4. The authors discovered that the dissociation of the Dynll1-Cox4i1 complex is required for the release of mitochondrial reactive oxygen species and serves as a regulator of intracellular proliferation of Listeria monocytogenes. The study shows that Dynll1 is an inhibitor of mitochondrial reactive oxygen species.
    Title: The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species.
  5. exercise training caused an increase in mRNA and protein levels of COXIV, whereas NAC intervention lowered the two so significantly that even exercise training could not reverse the effect of NAC intervention
    Title: The effect of treadmill training and N-acetyl-l-cysteine intervention on biogenesis of cytochrome c oxidase (COX).
  6. Data suggest that that obesity affects both sperm and seminal plasma composition; Cox4i1 mRNA is up-regulated in spermatozoa of obese mice compared to control mice.
    Title: Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model.
  7. Our data suggest that MPP(+) acts on astrocytes in a sex- and brain region-specific manner involving cytochrome c oxidase isoform expression in an impairment of energy production and elevated oxidative stress levels
    Title: Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability.
  8. Knockdown of small interfering RNA-mediated COX subunit IV decreases progesterone synthesis in steroidogenic cells.
    Title: Decreased cytochrome c oxidase IV expression reduces steroidogenesis.
  9. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
    Title: HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Names
cytochrome c oxidase polypeptide IV
cytochrome c oxidase subunit IV
cytochrome c oxidase, subunit IVa
NP_001280488.1
NP_034071.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293559.1 → NP_001280488.1  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001280488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK019276, AV469576, BE992841
    Consensus CDS
    CCDS40498.1
    UniProtKB/Swiss-Prot
    P19783, Q545A9
    UniProtKB/TrEMBL
    A2RSV8
    Related
    ENSMUSP00000138019.2, ENSMUST00000181586.8
    Conserved Domains (1) summary
    pfam02936
    Location:36 → 168
    COX4; Cytochrome c oxidase subunit IV

  2. NM_009941.3 → NP_034071.2  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK012583, BE992841, BY250039
    UniProtKB/Swiss-Prot
    P19783
    Conserved Domains (1) summary
    pfam02936
    Location:73 → 205
    COX4; Cytochrome c oxidase subunit IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121394964..121400948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19783.2 GenPept UniProtKB/Swiss-Prot:P19783

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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