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OR6P1 olfactory receptor family 6 subfamily P member 1 [ Homo sapiens (human) ]

Gene ID: 128366, updated on 5-Mar-2024

Summary

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Official Symbol
OR6P1provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily P member 1provided by HGNC
Primary source
HGNC:HGNC:15036
See related
Ensembl:ENSG00000186440 AllianceGenome:HGNC:15036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
mouse all
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Genomic context

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See OR6P1 in Genome Data Viewer
Location:
1q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158560606..158570580, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (157697705..157707679, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158530396..158540370, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heat shock protein 90 alpha family class A member 3, pseudogene Neighboring gene olfactory receptor family 6 subfamily Y member 1 Neighboring gene olfactory receptor family 10 subfamily X member 1 Neighboring gene olfactory receptor family 10 subfamily Z member 1 Neighboring gene spectrin alpha, erythrocytic 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A probabilistic classifier for olfactory receptor pseudogenes. Menashe I, et al. BMC Bioinformatics, 2006 Aug 29. PMID 16939646, Free PMC Article
  2. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 6P1
Names
olfactory receptor OR1-12
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160325.2 → NP_001153797.1  olfactory receptor 6P1

    See identical proteins and their annotated locations for NP_001153797.1

    Status: VALIDATED

    Source sequence(s)
    AL160283
    Consensus CDS
    CCDS53391.1
    UniProtKB/Swiss-Prot
    Q6IFR9, Q8NGX9
    UniProtKB/TrEMBL
    A0A126GV72
    Related
    ENSP00000492936.1, ENST00000641540.1
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33 → 303
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    158560606..158570580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    157697705..157707679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004287.3: Suppressed sequence

    Description
    NG_004287.3: This RefSeq was permanently suppressed because it is now thought that this pseudogene is a protein-coding gene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGX9.1 GenPept UniProtKB/Swiss-Prot:Q8NGX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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