U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C1orf162 chromosome 1 open reading frame 162 [ Homo sapiens (human) ]

Gene ID: 128346, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C1orf162provided by HGNC
Official Full Name
chromosome 1 open reading frame 162provided by HGNC
Primary source
HGNC:HGNC:28344
See related
Ensembl:ENSG00000143110 AllianceGenome:HGNC:28344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 7.0), appendix (RPKM 5.5) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111473984..111478512)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111481202..111493194)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112016606..112021134)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1496 Neighboring gene WD repeat domain 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1497 Neighboring gene ATP synthase peripheral stalk-membrane subunit b Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene RNA, U6 small nuclear 792, pseudogene Neighboring gene adenosine A3 receptor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. Pfefferle S, et al. PLoS Pathog, 2011 Oct. PMID 22046132, Free PMC Article
  2. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC24133

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein C1orf162

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300834.2 → NP_001287763.1  transmembrane protein C1orf162 isoform 2

    See identical proteins and their annotated locations for NP_001287763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BG545926, CA439311
    Consensus CDS
    CCDS72837.1
    UniProtKB/Swiss-Prot
    Q8NEQ5
    Related
    ENSP00000358732.3, ENST00000369718.4
    Conserved Domains (2) summary
    pfam15179
    Location:21 → 62
    Myc_target_1; Myc target protein 1
    cl27601
    Location:46 → 100
    Pectinesterase; Pectinesterase

  2. NM_001300835.2 → NP_001287764.1  transmembrane protein C1orf162 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AA333542, CA439311, HX785231

  3. NM_174896.4 → NP_777556.1  transmembrane protein C1orf162 isoform 1

    See identical proteins and their annotated locations for NP_777556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC017973, CA439311
    Consensus CDS
    CCDS837.1
    UniProtKB/Swiss-Prot
    Q5QNZ1, Q8NEQ5
    Related
    ENSP00000344218.5, ENST00000343534.9
    Conserved Domains (1) summary
    pfam15179
    Location:21 → 97
    Myc_target_1; Myc target protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    111473984..111478512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446258.1 → XP_047302214.1  transmembrane protein C1orf162 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    111481202..111493194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334454.1 → XP_054190429.1  transmembrane protein C1orf162 isoform X2

    UniProtKB/Swiss-Prot
    Q5QNZ1, Q8NEQ5

  2. XM_054334455.1 → XP_054190430.1  transmembrane protein C1orf162 isoform X3

  3. XM_054334456.1 → XP_054190431.1  transmembrane protein C1orf162 isoform X4

  4. XM_054334457.1 → XP_054190432.1  transmembrane protein C1orf162 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEQ5.1 GenPept UniProtKB/Swiss-Prot:Q8NEQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous