Col15a1 collagen, type XV, alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Col15a1provided by MGI
Official Full Name: collagen, type XV, alpha 1provided by MGI
Primary source: MGI:MGI:88449
See related: Ensembl:ENSMUSG00000028339 AllianceGenome:MGI:88449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be an extracellular matrix structural constituent. Predicted to be involved in angiogenesis; endothelial cell morphogenesis; and extracellular matrix organization. Predicted to act upstream of or within cell adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart and pericardium; and musculoskeletal system. Orthologous to human COL15A1 (collagen type XV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 90.5), genital fat pad adult (RPKM 48.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.01 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (47207744..47313165)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (47207655..47313167)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
Title: Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3E1 and MDPC23 by targeting COL15A1.
Title: Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3‑E1 and MDPC23 by targeting COL15A1.
The neuroprotection observed in ColXV KO mice may be attributed to the increased VEGF-A production following stroke in the ischemic territory.
Title: Lack of collagen XV is protective after ischemic stroke in mice.
loss of Col15a1resulted in marked attenuation rather than exacerbation of lesion pathogenesis
Title: Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions.
Basement membrane zone collagens XV and XVIII mediate leukocyte influx in renal ischemia-reperfusion.
Title: Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion.
Col XV is necessary for extracellular matrix organization in the heart, and for the structure and functions of microvessels. Col XV deficiency leads to a complex cardiac phenotype and predisposes the subject to pathological responses under cardiac stress.
Title: Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.
Collagen XV thus contributes to peripheral nerve maturation and C-fiber formation
Title: Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction.
collagens XV and XVIII have distinct roles as revealed by double knockout mice
Title: Double knockout mice reveal a lack of major functional compensation between collagens XV and XVIII.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AF011450 (e-PCR)
- UniSTS:159237

Col15a1 (e-PCR), detects polymorphism
- UniSTS:256934

D5Mco4 (e-PCR)
- UniSTS:240063

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring tensile strength	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent conferring tensile strength	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: collagen alpha-1(XV) chain

Names: procollagen type XV; type XV collagen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009928.3 → NP_034058.2 collagen alpha-1(XV) chain precursor

See identical proteins and their annotated locations for NP_034058.2

Status: VALIDATED

Source sequence(s)

AF011450, AK134030, CJ099231

Consensus CDS

CCDS18159.1

UniProtKB/Swiss-Prot

A2AJY3, O35206, Q3UZ71, Q9EQD9

UniProtKB/TrEMBL

A2AJY2

Related

ENSMUSP00000099981.5, ENSMUST00000102917.11

Conserved Domains (4) summary

smart00210
Location:42 → 228

TSPN; Thrombospondin N-terminal -like domains

pfam05109
Location:265 → 541

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01391
Location:641 → 690

Collagen; Collagen triple helix repeat (20 copies)

pfam06482
Location:1114 → 1361

Endostatin; Collagenase NC10 and Endostatin