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Cobl cordon-bleu WH2 repeat [ Mus musculus (house mouse) ]

Gene ID: 12808, updated on 9-Dec-2024

Summary

Official Symbol
Coblprovided by MGI
Official Full Name
cordon-bleu WH2 repeatprovided by MGI
Primary source
MGI:MGI:105056
See related
Ensembl:ENSMUSG00000020173 AllianceGenome:MGI:105056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables actin monomer binding activity. Involved in several processes, including actin filament organization; embryonic pattern specification; and positive regulation of cell projection organization. Acts upstream of or within actin cytoskeleton organization and neural tube closure. Located in several cellular components, including growth cone; ruffle; and terminal web. Colocalizes with actin filament. Is expressed in several structures, including central nervous system; chordamesoderm; embryo mesenchyme; gut; and nose. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in large intestine adult (RPKM 10.7), cortex adult (RPKM 8.5) and 21 other tissues See more
Orthologs
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Genomic context

See Cobl in Genome Data Viewer
Location:
11 A1; 11 7.3 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (12186676..12415022, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (12236676..12465022, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30423 Neighboring gene predicted gene, 24036 Neighboring gene STARR-seq mESC enhancer starr_28624 Neighboring gene STARR-seq mESC enhancer starr_28625 Neighboring gene predicted gene 12002 Neighboring gene STARR-seq mESC enhancer starr_28630 Neighboring gene STARR-seq mESC enhancer starr_28632 Neighboring gene prothymosin alpha-like Neighboring gene STARR-seq mESC enhancer starr_28634 Neighboring gene predicted gene, 22156

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • mKIAA0633, 4732460E13, C530045F18Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin monomer binding  
enables actin monomer binding PubMed 
enables actin monomer binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation PubMed 
acts_upstream_of_or_within actin cytoskeleton organization PubMed 
involved_in actin filament network formation  
involved_in actin filament network formation PubMed 
involved_in actin filament polymerization  
involved_in actin filament polymerization PubMed 
involved_in collateral sprouting in absence of injury PubMed 
involved_in digestive tract development PubMed 
involved_in embryonic axis specification PubMed 
involved_in floor plate development PubMed 
involved_in liver development PubMed 
acts_upstream_of_or_within neural tube closure PubMed 
involved_in notochord development PubMed 
involved_in positive regulation of dendrite development PubMed 
involved_in positive regulation of ruffle assembly PubMed 
involved_in somite specification PubMed 
Items 1 - 20 of 22
Component Evidence Code Pubs
colocalizes_with actin filament  
colocalizes_with actin filament PubMed 
located_in axon PubMed 
is_active_in axonal growth cone  
located_in axonal growth cone PubMed 
located_in cell cortex PubMed 
located_in cell cortex  
located_in dendrite PubMed 
is_active_in dendritic growth cone  
located_in dendritic growth cone PubMed 
located_in membrane PubMed 
is_active_in neuronal cell body  
located_in neuronal cell body PubMed 
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
is_active_in ruffle  
located_in ruffle PubMed 
is_active_in terminal web  
located_in terminal web PubMed 
Items 1 - 20 of 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282993.2NP_001269922.1  protein cordon-bleu isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL669822, AL713914
    Consensus CDS
    CCDS70144.1
    UniProtKB/TrEMBL
    B2RWU4, G5E8P4
    Related
    ENSMUSP00000105278.3, ENSMUST00000109651.9
    Conserved Domains (1) summary
    pfam09469
    Location:152229
    Cobl; Cordon-bleu ubiquitin-like domain
  2. NM_001282994.2NP_001269923.1  protein cordon-bleu isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL669822, AL713914
    Consensus CDS
    CCDS70142.1
    UniProtKB/TrEMBL
    B2RWU4, G3UWY3
    Related
    ENSMUSP00000133470.2, ENSMUST00000174874.8
    Conserved Domains (1) summary
    pfam09469
    Location:145222
    Cobl; Cordon-bleu ubiquitin-like domain
  3. NM_001401095.1NP_001388024.1  protein cordon-bleu isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
    UniProtKB/TrEMBL
    B2RWU4
  4. NM_001401096.1NP_001388025.1  protein cordon-bleu isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
    UniProtKB/TrEMBL
    B2RWU4
  5. NM_001401097.1NP_001388026.1  protein cordon-bleu isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
    UniProtKB/TrEMBL
    B2RWU4
    Related
    ENSMUSP00000105277.2, ENSMUST00000109650.8
  6. NM_001401098.1NP_001388027.1  protein cordon-bleu isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
    UniProtKB/TrEMBL
    G3UZ73
    Related
    ENSMUSP00000133669.2, ENSMUST00000172919.8
  7. NM_001401099.1NP_001388028.1  protein cordon-bleu isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
    UniProtKB/TrEMBL
    G3UZ73
    Related
    ENSMUSP00000134372.2, ENSMUST00000172956.8
  8. NM_001401100.1NP_001388029.1  protein cordon-bleu isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL669822, AL713914
  9. NM_172496.4NP_766084.3  protein cordon-bleu isoform 1

    See identical proteins and their annotated locations for NP_766084.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL669822, AL713914
    Consensus CDS
    CCDS36113.1
    UniProtKB/Swiss-Prot
    Q5NBX1, Q5NBX2, Q60859, Q6PAT4, Q7TQM9, Q80TV4, Q8C7Q0, Q8CE81, Q8CIM4
    UniProtKB/TrEMBL
    B2RWU4
    Related
    ENSMUSP00000045693.8, ENSMUST00000046755.14
    Conserved Domains (1) summary
    pfam09469
    Location:152229
    Cobl; Cordon-bleu ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    12186676..12415022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245514.1XP_030101374.1  protein cordon-bleu isoform X9

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152229
    Cobl; Cordon-bleu ubiquitin-like domain
  2. XM_011243653.4XP_011241955.1  protein cordon-bleu isoform X4

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152229
    Cobl; Cordon-bleu ubiquitin-like domain
  3. XM_011243654.3XP_011241956.1  protein cordon-bleu isoform X5

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152228
    Cobl; Cordon-bleu ubiquitin-like domain
  4. XM_011243656.3XP_011241958.1  protein cordon-bleu isoform X7

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152228
    Cobl; Cordon-bleu ubiquitin-like domain
  5. XM_006514481.4XP_006514544.1  protein cordon-bleu isoform X2

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152228
    Cobl; Cordon-bleu ubiquitin-like domain
  6. XM_011243651.4XP_011241953.1  protein cordon-bleu isoform X1

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:152228
    Cobl; Cordon-bleu ubiquitin-like domain
  7. XM_011243652.4XP_011241954.1  protein cordon-bleu isoform X3

    UniProtKB/TrEMBL
    B2RWU4
    Conserved Domains (1) summary
    pfam09469
    Location:141217
    Cobl; Cordon-bleu ubiquitin-like domain
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