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WDR64 WD repeat domain 64 [ Homo sapiens (human) ]

Gene ID: 128025, updated on 3-Apr-2024

Summary

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Official Symbol
WDR64provided by HGNC
Official Full Name
WD repeat domain 64provided by HGNC
Primary source
HGNC:HGNC:26570
See related
Ensembl:ENSG00000162843 AllianceGenome:HGNC:26570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.6) and placenta (RPKM 0.1) See more
Orthologs
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Genomic context

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Location:
1q43
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241652281..241802777)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (241063753..241214784)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241815583..241966079)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kynurenine 3-monooxygenase Neighboring gene opsin 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241802798-241803368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241803369-241803938 Neighboring gene uncharacterized LOC124904603 Neighboring gene CHM like Rab escort protein Neighboring gene CRISPRi-validated cis-regulatory element chr1.12743 Neighboring gene uncharacterized LOC105373231 Neighboring gene ribosomal protein L6 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Niu N, et al. Genome Res, 2010 Nov. PMID 20923822, Free PMC Article
  2. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. McCauley JL, et al. Genes Immun, 2009 Oct. PMID 19626040, Free PMC Article
  3. A genome-wide association study of behavioral disinhibition. McGue M, et al. Behav Genet, 2013 Sep. PMID 23942779, Free PMC Article
  4. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  5. Physical and functional interactome atlas of human receptor tyrosine kinases. Salokas K, et al. EMBO Rep, 2022 Jun 7. PMID 35384245, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32978

General protein information

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Preferred Names
WD repeat-containing protein 64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367482.1 → NP_001354411.1  WD repeat-containing protein 64

    Status: VALIDATED

    Source sequence(s)
    AL365366, BX248405, BX322532
    Consensus CDS
    CCDS91185.1
    UniProtKB/Swiss-Prot
    B1ANS9, B1ANT0, Q7Z573, Q96LY9
    UniProtKB/TrEMBL
    A0A0C4DG52
    Related
    ENSP00000402446.4, ENST00000437684.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    241652281..241802777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544087.3 → XP_011542389.1  WD repeat-containing protein 64 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:91 → 538
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:468 → 505
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:284 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_011544091.2 → XP_011542393.1  WD repeat-containing protein 64 isoform X4

    Conserved Domains (3) summary
    COG2319
    Location:91 → 538
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:468 → 505
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:284 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_011544092.3 → XP_011542394.1  WD repeat-containing protein 64 isoform X5

    Conserved Domains (3) summary
    COG2319
    Location:91 → 538
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:468 → 505
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:284 → 538
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_017000315.2 → XP_016855804.1  WD repeat-containing protein 64 isoform X1

    UniProtKB/Swiss-Prot
    B1ANS9, B1ANT0, Q7Z573, Q96LY9

  5. XM_011544086.4 → XP_011542388.1  WD repeat-containing protein 64 isoform X2

    See identical proteins and their annotated locations for XP_011542388.1

    UniProtKB/Swiss-Prot
    B1ANS9, B1ANT0, Q7Z573, Q96LY9
    Conserved Domains (3) summary
    COG2319
    Location:85 → 545
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:307 → 344
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:123 → 377
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_047445900.1 → XP_047301856.1  WD repeat-containing protein 64 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    241063753..241214784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334409.1 → XP_054190384.1  WD repeat-containing protein 64 isoform X3

  2. XM_054334410.1 → XP_054190385.1  WD repeat-containing protein 64 isoform X4

  3. XM_054334411.1 → XP_054190386.1  WD repeat-containing protein 64 isoform X5

  4. XM_054334406.1 → XP_054190381.1  WD repeat-containing protein 64 isoform X1

  5. XM_054334408.1 → XP_054190383.1  WD repeat-containing protein 64 isoform X2

  6. XM_054334407.1 → XP_054190382.1  WD repeat-containing protein 64 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144625.4: Suppressed sequence

    Description
    NM_144625.4: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1ANS9.1 GenPept UniProtKB/Swiss-Prot:B1ANS9

Gene LinkOut

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