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Cnbp cellular nucleic acid binding protein [ Mus musculus (house mouse) ]

Gene ID: 12785, updated on 2-May-2024

Summary

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Official Symbol
Cnbpprovided by MGI
Official Full Name
cellular nucleic acid binding proteinprovided by MGI
Primary source
MGI:MGI:88431
See related
Ensembl:ENSMUSG00000030057 AllianceGenome:MGI:88431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf9; Cnbp1
Summary
Predicted to enable nucleic acid binding activity and translation regulator activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in cytosol; endoplasmic reticulum; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 105.5), liver E14 (RPKM 104.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 39.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (87819597..87828088, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87842615..87851106, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16566 Neighboring gene RAB43, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E10388 Neighboring gene STARR-positive B cell enhancer ABC_E11324 Neighboring gene STARR-seq mESC enhancer starr_16567 Neighboring gene ISY1 splicing factor homolog Neighboring gene STARR-seq mESC enhancer starr_16568 Neighboring gene STARR-positive B cell enhancer ABC_E2793 Neighboring gene coatomer protein complex, subunit gamma 1 Neighboring gene STARR-positive B cell enhancer ABC_E1704 Neighboring gene 5-hydroxymethylcytosine (hmC) binding, ES cell specific Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CNBP controls tumor cell biology by regulating tumor-promoting gene expression. Lee E, et al. Mol Carcinog, 2019 Aug. PMID 31087358
  2. Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice. Zheng B, et al. Reproduction, 2018 Jul. PMID 29743260
  3. Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy. Wei C, et al. Mol Cell Biol, 2018 Jul 15. PMID 29735719, Free PMC Article
  4. APP(DeltaNL695) expression in murine tissue downregulates CNBP expression. Niedowicz DM, et al. Neurosci Lett, 2010 Sep 20. PMID 20621159, Free PMC Article
  5. Dissecting CNBP, a zinc-finger protein required for neural crest development, in its structural and functional domains. Armas P, et al. J Mol Biol, 2008 Oct 17. PMID 18703071

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating beta-catenin signaling.
    Title: Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
  2. Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
    Title: Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
  3. The findings reveal CNBP as a key transcriptional regulator of tumor-promoting target genes to control tumor cell biology.
    Title: CNBP controls tumor cell biology by regulating tumor-promoting gene expression.
  4. these findings identify CNBP as important regulator of c-Rel-dependent IL-12beta gene transcription and Th1 immunity.
    Title: CNBP controls IL-12 gene transcription and Th1 immunity.
  5. A loss of Cnbp disturbs myofibrillar sarcomeric organization at birth. Surviving homozygous Cnbp KO mice develop muscle atrophy at a young age. The skeletal muscle phenotype in heterozygous Cnbp KO mice was milder, but they developed severe muscle wasting at an advanced age.
    Title: Reduction of Cellular Nucleic Acid Binding Protein Encoded by a Myotonic Dystrophy Type 2 Gene Causes Muscle Atrophy.
  6. our study suggests that CNBP could maintain testicular development by inhibiting the Wnt/beta-catenin pathway, particularly by influencing Sertoli cells.
    Title: Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice.
  7. A G-rich motif in the lncRNA Braveheart interacts with Cnbp to specify the cardiovascular lineage.
    Title: A G-Rich Motif in the lncRNA Braveheart Interacts with a Zinc-Finger Transcription Factor to Specify the Cardiovascular Lineage.
  8. data support a role for CNBP as a critical transcription factor and a key regulator of the prolonged expression of sustained cytokine IL-6 during persistent LPS stimulation or Gram-negative bacterial infection
    Title: CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6.
  9. CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
    Title: Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development.
  10. expression of APP(Swe) in murine tissue induces a decrease in CNBP expression.
    Title: APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Transgenic (1)  1 citation
  • Targeted (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G-quadruplex DNA formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CCHC-type zinc finger nucleic acid binding protein
Names
cellular nucleic acid binding protein 1
zinc finger protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109745.1 → NP_001103215.1  CCHC-type zinc finger nucleic acid binding protein isoform 2

    See identical proteins and their annotated locations for NP_001103215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AK078427, AK144740, AK159810, CJ088264
    UniProtKB/TrEMBL
    Q3U5V2
    Conserved Domains (1) summary
    PTZ00368
    Location:47 → 165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  2. NM_001109746.1 → NP_001103216.1  CCHC-type zinc finger nucleic acid binding protein isoform 3

    See identical proteins and their annotated locations for NP_001103216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (3) differs in the middle region and has identical N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AK144740, AK151961, CJ088264
    Consensus CDS
    CCDS85092.1
    UniProtKB/TrEMBL
    Q3U935
    Related
    ENSMUSP00000109249.3, ENSMUST00000113619.8
    Conserved Domains (1) summary
    PTZ00368
    Location:47 → 164
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  3. NM_001347325.1 → NP_001334254.1  CCHC-type zinc finger nucleic acid binding protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (4) lacks one amino acid, as compared to isoform 1.
    Source sequence(s)
    AK075760, AK144740, AK147157, CJ088264
    Consensus CDS
    CCDS85091.1
    UniProtKB/TrEMBL
    D3YYF6, Q3ULK8
    Related
    ENSMUSP00000145274.2, ENSMUST00000204653.3
    Conserved Domains (1) summary
    PTZ00368
    Location:54 → 171
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  4. NM_001355195.1 → NP_001342124.1  CCHC-type zinc finger nucleic acid binding protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (5) lacks an internal segment and has identical N- and C-termini, as compared to isoform 1. Isoforms 2 and 5 are the same length but have distinct sequences.
    Source sequence(s)
    AK144740, AK147157, CJ088264
    Consensus CDS
    CCDS90085.1
    UniProtKB/TrEMBL
    A0A0N4SVS6
    Related
    ENSMUSP00000145227.2, ENSMUST00000204890.3
    Conserved Domains (1) summary
    PTZ00368
    Location:48 → 165
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

  5. NM_013493.3 → NP_038521.1  CCHC-type zinc finger nucleic acid binding protein isoform 1

    See identical proteins and their annotated locations for NP_038521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK144740, BC058723, CJ088264
    Consensus CDS
    CCDS51841.1
    UniProtKB/Swiss-Prot
    P53996, Q80Y06, Q8BP23
    UniProtKB/TrEMBL
    Q5QJQ9
    Related
    ENSMUSP00000032138.9, ENSMUST00000032138.15
    Conserved Domains (1) summary
    PTZ00368
    Location:54 → 172
    PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    87819597..87828088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53996.2 GenPept UniProtKB/Swiss-Prot:P53996

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