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LINC00628 long intergenic non-protein coding RNA 628 [ Homo sapiens (human) ]

Gene ID: 127841, updated on 10-Oct-2023

Summary

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Official Symbol
LINC00628provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 628provided by HGNC
Primary source
HGNC:HGNC:27008
See related
Ensembl:ENSG00000280924 AllianceGenome:HGNC:27008
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
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Genomic context

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Location:
1q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (204368430..204369719, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (203632979..203634268, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (204337558..204338847, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204182987-204183643 Neighboring gene golgi transport 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204191229-204191730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204191731-204192230 Neighboring gene pleckstrin homology domain containing A6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204222775-204223276 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204223277-204223776 Neighboring gene HNF1 motif-containing MPRA enhancer 91/92 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204244227-204245062 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:204251843-204252046 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:204252631-204253132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:204253133-204253632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204264456-204265347 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204273055-204273675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204291013-204291512 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:204305671-204306454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204307239-204308022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204309736-204310344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204317722-204318460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204326340-204327267 Neighboring gene ribosomal protein L21 pseudogene 19 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204327268-204328194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204328310-204328945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:204331933-204332486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2360 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:204379922-204380756 Neighboring gene protein phosphatase 1 regulatory subunit 15B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Downregulated LINC00628 aggravates the progression of colorectal cancer via inhibiting p57 level. Zhang MC, et al. Eur Rev Med Pharmacol Sci, 2020 Feb. PMID 32141544
  2. LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma. He R, et al. Eur Rev Med Pharmacol Sci, 2018 Sep. PMID 30280767
  3. Long non-coding RNA LINC00628 suppresses the growth and metastasis and promotes cell apoptosis in breast cancer. Chen DQ, et al. Eur Rev Med Pharmacol Sci, 2017 Jan. PMID 28165561
  4. Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes. Zhang ZZ, et al. Sci Rep, 2016 Jun 8. PMID 27272474, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulated LINC00628 aggravates the progression of colorectal cancer via inhibiting p57 level.
    Title: Downregulated LINC00628 aggravates the progression of colorectal cancer via inhibiting p57 level.
  2. Results demostrated that LINC00628 expression was decreased in osteosarcoma. The overexpression of LINC00628 inhibited the proliferation, invasion and migration and promoted cell apoptosis in osteosarcoma cells through the inactivation of PI3K/Akt signaling pathway. The study indicated that LINC00628 may be a biomarker for the prognosis of osteosarcoma patients.
    Title: LncRNA LINC00628 overexpression inhibits the growth and invasion through regulating PI3K/Akt signaling pathway in osteosarcoma.
  3. confirmed that LINC00628 mainly located in the nucleus and interacted with EZH2, and modulated genes expression by regulating H3K27me3 level
    Title: Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027022.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606489
    Related
    ENST00000628516.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    204368430..204369719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    203632979..203634268 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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