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LOC127829845 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:66696135-66696928 [ Homo sapiens (human) ]

Gene ID: 127829845, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127829845
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:66696135-66696928
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127829845 in Genome Data Viewer
Location:
chromosome: 15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (66403797..66404590)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (64225249..64226042)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TIMELESS interacting protein Neighboring gene small Cajal body-specific RNA 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6564 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66681899-66682075 Neighboring gene ribosomal protein L9 pseudogene 25 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6565 Neighboring gene ATP synthase membrane subunit f pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66720755-66721254 Neighboring gene ribosomal protein L35a pseudogene 32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_131327.1 

    Range
    101..894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    66403797..66404590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    64225249..64226042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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