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LOC127825719 H3K27ac hESC enhancer GRCh37_chr12:131339443-131340192 [ Homo sapiens (human) ]

Gene ID: 127825719, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127825719
Gene description
H3K27ac hESC enhancer GRCh37_chr12:131339443-131340192
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (130854898..130855647)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (130893995..130894744)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131246445-131247250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7345 Neighboring gene Sharpr-MPRA regulatory region 14372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:131271649-131272370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:131272371-131273092 Neighboring gene Sharpr-MPRA regulatory region 967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7346 Neighboring gene syntaxin 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:131290439-131291361 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:131296228-131296411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7347 Neighboring gene uncharacterized LOC124903117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5090 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5092 Neighboring gene Sharpr-MPRA regulatory region 8535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131335999-131336907 Neighboring gene uncharacterized LOC124903053 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:131337941-131338691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:131338692-131339442 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:131355651-131356412 and GRCh37_chr12:131356413-131357174 Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7349 Neighboring gene RAN, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_127231.1 

    Range
    101..850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    130854898..130855647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    130893995..130894744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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