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LOC127823080 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:130253373-130253917 [ Homo sapiens (human) ]

Gene ID: 127823080, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127823080
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:130253373-130253917
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (130383478..130384022)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (130419286..130419830)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene uncharacterized LOC124902848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4081 Neighboring gene RNA, 7SL, cytoplasmic 778, pseudogene Neighboring gene ZBTB44 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr11:130240792-130241293 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:130248135-130248650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130289647-130290148 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8 Neighboring gene NANOG hESC enhancer GRCh37_chr11:130321509-130322010 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_124519.1 

    Range
    101..645
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    130383478..130384022
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    130419286..130419830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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