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Ccr9 C-C motif chemokine receptor 9 [ Mus musculus (house mouse) ]

Gene ID: 12769, updated on 11-Apr-2024

Summary

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Official Symbol
Ccr9provided by MGI
Official Full Name
C-C motif chemokine receptor 9provided by MGI
Primary source
MGI:MGI:1341902
See related
Ensembl:ENSMUSG00000029530 AllianceGenome:MGI:1341902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cmkbr10; GPR-9-6; A130091K22Rik
Summary
Enables C-C chemokine receptor activity. Acts upstream of or within CD8-positive, gamma-delta intraepithelial T cell differentiation and chemotaxis. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; immune system; and retina. Orthologous to human CCR9 (C-C motif chemokine receptor 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward thymus adult (RPKM 118.6) See more
Orthologs
human all
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Genomic context

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See Ccr9 in Genome Data Viewer
Location:
9 F4; 9 74.33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123596276..123612522)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123767211..123783457)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25570 Neighboring gene leucine zipper transcription factor-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626087-123626387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626696-123626997 Neighboring gene STARR-seq mESC enhancer starr_25571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123663531-123663880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123665948-123666172 Neighboring gene predicted gene 17021 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123693813-123694114 Neighboring gene FYVE and coiled-coil domain containing 1 Neighboring gene C-X-C motif chemokine receptor 6 Neighboring gene STARR-seq mESC enhancer starr_25572 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123760971-123761272 Neighboring gene predicted gene, 51700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury. Koda Y, et al. JCI Insight, 2022 Sep 8. PMID 35943802, Free PMC Article
  2. Abrogation of CC Chemokine Receptor 9 Ameliorates Ventricular Electrical Remodeling in Mice After Myocardial Infarction. Huang Y, et al. Front Cardiovasc Med, 2021. PMID 34712704, Free PMC Article
  3. C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. Amiya T, et al. Diabetologia, 2021 Mar. PMID 33399911
  4. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction. Huang Y, et al. Sci Rep, 2016 Sep 2. PMID 27585634, Free PMC Article
  5. Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. Evans-Marin HL, et al. PLoS One, 2015. PMID 26230654, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of chemokine receptor 9 facilitates CD4[+]CD8alphaalpha[+] intraepithelial lymphocyte development.
    Title: Downregulation of chemokine receptor 9 facilitates CD4(+)CD8αα(+) intraepithelial lymphocyte development.
  2. CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury.
    Title: CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury.
  3. Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and alpha4beta7 Integrin and Direct Their Migration In Vitro.
    Title: Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
  4. C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
    Title: C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
  5. The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation.
    Title: The Heteromeric Complex Formed by Dopamine Receptor D(5) and CCR9 Leads the Gut Homing of CD4(+) T Cells Upon Inflammation.
  6. Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis.
    Title: Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis.
  7. The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
    Title: The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo.
  8. Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
    Title: Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis.
  9. Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
    Title: Toll-Like Receptor 4 Promotes Th17 Lymphocyte Infiltration Via CCL25/CCR9 in Pathogenesis of Experimental Autoimmune Encephalomyelitis.
  10. our observations of increased circulating CCR9+ IL-17+ Treg cells and its inverse correlation with the severity of intestinal tissue injury in NEC are novel
    Title: Interleukin-6-mediated CCR9(+) interleukin-17-producing regulatory T cells polarization increases the severity of necrotizing enterocolitis.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-C chemokine receptor type 9
Names
C-C CKR-9
CC-CKR-9
CCR-9
chemokine (C-C motif) receptor 9
chemokine C-C receptor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166625.1 → NP_001160097.1  C-C chemokine receptor type 9

    See identical proteins and their annotated locations for NP_001160097.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC165425
    Consensus CDS
    CCDS23662.1
    UniProtKB/Swiss-Prot
    A2RSM5, Q543I4, Q9WUT7
    UniProtKB/TrEMBL
    F8WIS0
    Related
    ENSMUSP00000126758.2, ENSMUST00000168910.2
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 317
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_009913.6 → NP_034043.1  C-C chemokine receptor type 9

    See identical proteins and their annotated locations for NP_034043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC165425, AK050615
    Consensus CDS
    CCDS23662.1
    UniProtKB/Swiss-Prot
    A2RSM5, Q543I4, Q9WUT7
    UniProtKB/TrEMBL
    F8WIS0
    Related
    ENSMUSP00000127024.2, ENSMUST00000166236.9
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 317
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123596276..123612522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUT7.1 GenPept UniProtKB/Swiss-Prot:Q9WUT7

Gene LinkOut

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