Clu clusterin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cluprovided by MGI
Official Full Name: clusterinprovided by MGI
Primary source: MGI:MGI:88423
See related: Ensembl:ENSMUSG00000022037 AllianceGenome:MGI:88423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; D14Ucla3
Summary: The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]
Expression: Biased expression in genital fat pad adult (RPKM 3056.5), ovary adult (RPKM 788.7) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 34.36 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (66206093..66218992)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (65968483..65981548)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secretory Clusterin Inhibits Dopamine Neuron Apoptosis in MPTP Mice by Preserving Autophagy Activity.
Title: Secretory Clusterin Inhibits Dopamine Neuron Apoptosis in MPTP Mice by Preserving Autophagy Activity.
Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin.
Title: Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin.
Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
Title: Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury.
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of beta-amyloid peptides.
Title: BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides.
N6-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis.
Title: N6-Methyladenosine Methyltransferase METTL3 Alleviates Diabetes-Induced Testicular Damage through Modulating TUG1/Clusterin Axis.
The functions of clusterin in renal mesenchymal stromal cells: Promotion of cell growth and regulation of macrophage activation.
Title: The functions of clusterin in renal mesenchymal stromal cells: Promotion of cell growth and regulation of macrophage activation.
Glutathione S-Transferase and Clusterin, New Players in the Ischemic Preconditioning Renal Protection in a Murine Model of Ischemia and Reperfusion.
Title: Glutathione S-Transferase and Clusterin, New Players in the Ischemic Preconditioning Renal Protection in a Murine Model of Ischemia and Reperfusion.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Title: Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Clusterin Deficiency Exacerbates Hyperoxia-Induced Acute Lung Injury.
Title: Clusterin Deficiency Exacerbates Hyperoxia-Induced Acute Lung Injury.
Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.
Title: Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes-induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94609 (e-PCR)
- UniSTS:119857

Clu (e-PCR), detects polymorphism
- UniSTS:525479

Clu (e-PCR), detects polymorphism
- UniSTS:506804

Clu (e-PCR), detects polymorphism
- UniSTS:532420

D15Wox9 (e-PCR)
- UniSTS:518857

AI893575 (e-PCR)
- UniSTS:180685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein carrier chaperone	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in immune complex clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurofibrillary tangle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein import	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to misfolded protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
colocalizes_with cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
colocalizes_with membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neurofibrillary tangle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: clusterin

Names: Apolipoprotein J; clustrin; complement lysis inhibitor; sulfated glycoprotein 2; testosterone repressed prostate message; testosterone repressed prostate message-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001422221.1 → NP_001409150.1 clusterin preproprotein

Status: REVIEWED

Source sequence(s)

AC126444

UniProtKB/Swiss-Prot

Q06890

UniProtKB/TrEMBL

Q549A5
NM_001422222.1 → NP_001409151.1 clusterin preproprotein

Status: REVIEWED

Source sequence(s)

AC126444

UniProtKB/Swiss-Prot

Q06890

UniProtKB/TrEMBL

Q549A5
NM_001422223.1 → NP_001409152.1 clusterin preproprotein

Status: REVIEWED

Source sequence(s)

AC126444

UniProtKB/Swiss-Prot

Q06890

UniProtKB/TrEMBL

Q549A5
NM_001422224.1 → NP_001409153.1 clusterin preproprotein

Status: REVIEWED

Source sequence(s)

AC126444

UniProtKB/Swiss-Prot

Q06890

UniProtKB/TrEMBL

Q549A5
NM_013492.4 → NP_038520.2 clusterin preproprotein

See identical proteins and their annotated locations for NP_038520.2

Status: REVIEWED

Source sequence(s)

AC126444

Consensus CDS

CCDS36957.1

UniProtKB/Swiss-Prot

Q06890

UniProtKB/TrEMBL

Q549A5, Q9JK98

Related

ENSMUSP00000022616.7, ENSMUST00000022616.14

Conserved Domains (1) summary

pfam01093
Location:29 → 444

Clusterin