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LOC127457291 H3K27ac hESC enhancer GRCh37_chr7:101949043-101949828 [ Homo sapiens (human) ]

Gene ID: 127457291, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127457291
Gene description
H3K27ac hESC enhancer GRCh37_chr7:101949043-101949828
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127457291 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102305759..102306545)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103623156..103623941)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cut like homeobox 1 Neighboring gene uncharacterized LOC124901711 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:101911196-101911353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101917405-101918238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101922504-101923122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101923123-101923741 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:101927516-101927700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18499 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:101937369-101938122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:101951399-101952183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101957283-101957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101957935-101958585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101959159-101959659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101960288-101961000 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:101962426-101963137 Neighboring gene uncharacterized LOC107986717 Neighboring gene microRNA 4285 Neighboring gene SH2B adaptor protein 2 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 26424

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_112065.1 

    Range
    101..887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    102305759..102306545
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    103623156..103623941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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