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LOC127406163 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39422591-39423265 [ Homo sapiens (human) ]

Gene ID: 127406163, updated on 10-Oct-2023

Summary

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Gene symbol
LOC127406163
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:39422591-39423265
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (39454815..39455489)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (39279358..39280032)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39307295-39307796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39311103-39311940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39312615-39313116 Neighboring gene potassium two pore domain channel subfamily K member 16 Neighboring gene uncharacterized LOC107986594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39321781-39322280 Neighboring gene ANKRD39 pseudogene 1 Neighboring gene kinesin family member 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:39384626-39385126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24495 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:39500871-39501060 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:39508271-39508448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:39522677-39523579 Neighboring gene E2F transcription factor 4 pseudogene 1 Neighboring gene RNA, U1 small nuclear 54, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_108134.1 

    Range
    101..775
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    39454815..39455489
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    39279358..39280032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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