U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127267589 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15480425-15481086 [ Homo sapiens (human) ]

Gene ID: 127267589, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC127267589
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15480425-15481086
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes three accessible chromatin subregions, two of which were validated as silencers and one as an enhancer based on their ability to repress or activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (15153900..15154590)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (14597967..14598657)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kazrin, periplakin interacting protein Neighboring gene uncharacterized LOC124903849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15249981-15250480 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:15261293-15261469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15266300-15266801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15270527-15271122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15273767-15274267 Neighboring gene Sharpr-MPRA regulatory region 2794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15296544-15297266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15294452-15295356 Neighboring gene Sharpr-MPRA regulatory region 10909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15347400-15348061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15348723-15349384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 230 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15379147-15379811 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15379812-15380475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15386302-15386802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15386803-15387303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:15390134-15391333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15427206-15427915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15438360-15438939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15438940-15439518 Neighboring gene TMEM51 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:15481087-15481748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 296 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 299 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15513533-15514104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:15514105-15514677 Neighboring gene TMEM51 antisense RNA 2 Neighboring gene transmembrane protein 51 Neighboring gene MFF pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers across the chromatin accessible human genome. Hansen TJ, et al. Genome Res, 2022 Jul 20. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 232
  • ATAC-STARR-seq lymphoblastoid silent region 297
  • ATAC-STARR-seq lymphoblastoid silent region 298

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_089464.2 

    Range
    101..791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    15153900..15154590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    14597967..14598657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases