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LOC126861863 BRD4-independent group 4 enhancer GRCh37_chr13:112837781-112838980 [ Homo sapiens (human) ]

Gene ID: 126861863, updated on 10-Oct-2023

Summary

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Gene symbol
LOC126861863
Gene description
BRD4-independent group 4 enhancer GRCh37_chr13:112837781-112838980
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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Location:
chromosome: 13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112183467..112184666)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (111427529..111428728)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene SOX1 overlapping transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112760473-112761092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112761713-112762331 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:112766326-112767525 Neighboring gene long intergenic non-protein coding RNA 404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112805199-112805774 Neighboring gene uncharacterized LOC100506016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112813701-112814406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112814407-112815111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112817596-112818292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112818293-112818987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112826532-112827032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112827033-112827533 Neighboring gene uncharacterized LOC105370370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr13:112843656-112844855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112853773-112854272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112856695-112857488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112857489-112858280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112859075-112859866 Neighboring gene uncharacterized LOC124903249 Neighboring gene long intergenic non-protein coding RNA 1070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112865406-112866297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086361.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    112183467..112184666
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187592.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    593..1792
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    111427529..111428728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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