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GABPB2 GA binding protein transcription factor subunit beta 2 [ Homo sapiens (human) ]

Gene ID: 126626, updated on 5-Mar-2024

Summary

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Official Symbol
GABPB2provided by HGNC
Official Full Name
GA binding protein transcription factor subunit beta 2provided by HGNC
Primary source
HGNC:HGNC:28441
See related
Ensembl:ENSG00000143458 AllianceGenome:HGNC:28441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GABPB-2
Summary
Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. The gene on Hsa1q was named GABPB2 and the gene on Hsa15q was named GABPB1. [24 Sep 2008]
Expression
Ubiquitous expression in testis (RPKM 4.7), ovary (RPKM 3.2) and 25 other tissues See more
Orthologs
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Genomic context

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See GABPB2 in Genome Data Viewer
Location:
1q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151070761..151125542)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150194444..150249243)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151043237..151098018)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 56 Neighboring gene CDC42 small effector 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1309 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1310 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:151032419-151033010 Neighboring gene MLLT11 transcription factor 7 cofactor Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151042752-151043686 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151043687-151044621 Neighboring gene ribosomal protein S29 pseudogene 29 Neighboring gene uncharacterized LOC124904418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:151104130-151104914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1313 Neighboring gene semaphorin 6C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors. Sawa C, et al. J Biol Chem, 2002 Jun 21. PMID 11953439
  2. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. Du K, et al. J Biol Chem, 1998 Dec 25. PMID 9857059
  3. Molecular and genetic characterization of GABP beta. de la Brousse FC, et al. Genes Dev, 1994 Aug 1. PMID 7958862
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Flachsbart F, et al. Mutat Res, 2010 Dec 10. PMID 20800603

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of GA binding protein transcription factor, beta subunit 2 (GABPB2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GA-binding protein subunit beta-2
Names
GA binding protein transcription factor beta subunit 2
GABP subunit beta-2
NP_001310835.1
NP_001310836.1
NP_001310837.1
NP_001310838.1
NP_001310839.1
NP_001310840.1
NP_001310841.1
NP_001310842.1
NP_653219.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323906.2 → NP_001310835.1  GA-binding protein subunit beta-2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924

  2. NM_001323907.2 → NP_001310836.1  GA-binding protein subunit beta-2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467

  3. NM_001323908.2 → NP_001310837.1  GA-binding protein subunit beta-2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    B1AVJ8, D3DV14, Q8NAR5, Q8TAK5
    UniProtKB/TrEMBL
    B2R924
    Conserved Domains (2) summary
    cd00204
    Location:34 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]

  4. NM_001323909.2 → NP_001310838.1  GA-binding protein subunit beta-2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    Consensus CDS
    CCDS81373.1
    UniProtKB/TrEMBL
    B2R924, Q5SZG2
    Related
    ENSP00000357912.1, ENST00000368916.1
    Conserved Domains (4) summary
    cd00204
    Location:34 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:42 → 132
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 58
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]

  5. NM_001323910.2 → NP_001310839.1  GA-binding protein subunit beta-2 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924
    Conserved Domains (5) summary
    cd00204
    Location:54 → 172
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:58 → 148
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:10 → 74
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:54 → 84
    ANK; ANK repeat [structural motif]
    cl03075
    Location:349 → 406
    GrpE; nucleotide exchange factor GrpE

  6. NM_001323911.2 → NP_001310840.1  GA-binding protein subunit beta-2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467
    UniProtKB/TrEMBL
    B2R924

  7. NM_001323912.2 → NP_001310841.1  GA-binding protein subunit beta-2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467

  8. NM_001323913.2 → NP_001310842.1  GA-binding protein subunit beta-2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL590133, AL592424, AL691467

  9. NM_144618.3 → NP_653219.1  GA-binding protein subunit beta-2 isoform a

    See identical proteins and their annotated locations for NP_653219.1

    Status: VALIDATED

    Source sequence(s)
    AL592424, BC027033
    Consensus CDS
    CCDS983.1
    UniProtKB/Swiss-Prot
    B1AVJ8, D3DV14, Q8NAR5, Q8TAK5
    UniProtKB/TrEMBL
    B2R924
    Related
    ENSP00000357914.3, ENST00000368918.8
    Conserved Domains (2) summary
    cd00204
    Location:34 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:38 → 68
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151070761..151125542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150194444..150249243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TAK5.1 GenPept UniProtKB/Swiss-Prot:Q8TAK5

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