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NR2C2AP nuclear receptor 2C2 associated protein [ Homo sapiens (human) ]

Gene ID: 126382, updated on 5-Mar-2024

Summary

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Official Symbol
NR2C2APprovided by HGNC
Official Full Name
nuclear receptor 2C2 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:30763
See related
Ensembl:ENSG00000184162 MIM:608719; AllianceGenome:HGNC:30763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRA16
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 9.3), skin (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19201409..19203414, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19337959..19339964, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19312218..19314223, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BORCS8-MEF2B readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14339 Neighboring gene myocyte enhancer factor 2B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19271207-19272182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19281232-19281995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:19282939-19283545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19285189-19285690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:19296281-19296782 Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14342 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:19305905-19306056 Neighboring gene regulatory factor X associated ankyrin containing protein Neighboring gene ReSE screen-validated silencer GRCh37_chr19:19313199-19313465 Neighboring gene Sharpr-MPRA regulatory region 11890 Neighboring gene Sharpr-MPRA regulatory region 3423 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:19324416-19324916 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:19324917-19325417 Neighboring gene neurocan Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14343 Neighboring gene RNA, U6 small nuclear 1028, pseudogene Neighboring gene hyaluronan and proteoglycan link protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2. Fang F, et al. Oncol Rep, 2013 Jan. PMID 23129017, Free PMC Article
  2. Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. Wang CP, et al. Biochem Biophys Res Commun, 2006 Dec 8. PMID 17054912
  3. Evaluating the Cornell Scale for Depression in Dementia as a proxy measure in nursing home residents with and without dementia. Towsley G, et al. Aging Ment Health, 2012. PMID 22486638, Free PMC Article
  4. Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation. Yang Y, et al. J Biol Chem, 2003 Feb 28. PMID 12486131
  5. Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor. Lee YF, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381082

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High TRA16 expression promotes small cell lung carcinoma by activating estrogen receptor beta and blocking testicular orphan nuclear receptor 2
    Title: Testicular orphan nuclear receptor 4-associated protein 16 promotes non-small cell lung carcinoma by activating estrogen receptor β and blocking testicular orphan nuclear receptor 2.
  2. Together, these findings provide the first in vivo evidence that an orphan nuclear receptor, such as TR4, may play major roles in the RA-mediated apoptosis or differentiation in P19 cells.
    Title: Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor.
  3. TRA16 may function as a novel repressor to selectively suppress the TR4-mediated transactivation
    Title: Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation.
  4. Taken together, these results suggested that TR4 should be one of important regulators of OXT gene expression.
    Title: Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of nuclear receptor 2C2-associated protein (NR2C2AP) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
nuclear receptor 2C2-associated protein
Names
TR4 orphan receptor associated protein TRA16
TR4 orphan receptor-associated 16 kDa protein
repressor for TR4 transactivation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300945.2 → NP_001287874.1  nuclear receptor 2C2-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001287874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA588235, AK301426, HY088736
    Consensus CDS
    CCDS74316.1
    UniProtKB/Swiss-Prot
    Q86WQ0
    Related
    ENSP00000402756.1, ENST00000420605.7

  2. NM_176880.6 → NP_795361.1  nuclear receptor 2C2-associated protein isoform 2

    See identical proteins and their annotated locations for NP_795361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' terminal exon, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA588235, BC057837, HY088736
    Consensus CDS
    CCDS32967.1
    UniProtKB/Swiss-Prot
    A6NGP7, B4DW92, Q86WQ0
    Related
    ENSP00000332823.6, ENST00000331552.12
    Conserved Domains (1) summary
    cl23730
    Location:38 → 138
    F5_F8_type_C; F5/8 type C domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    19201409..19203414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19337959..19339964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WQ0.1 GenPept UniProtKB/Swiss-Prot:Q86WQ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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