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TNFAIP8L1 TNF alpha induced protein 8 like 1 [ Homo sapiens (human) ]

Gene ID: 126282, updated on 5-Mar-2024

Summary

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Official Symbol
TNFAIP8L1provided by HGNC
Official Full Name
TNF alpha induced protein 8 like 1provided by HGNC
Primary source
HGNC:HGNC:28279
See related
Ensembl:ENSG00000185361 MIM:615869; AllianceGenome:HGNC:28279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIPE1
Summary
Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 6.4), spleen (RPKM 5.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
19p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4639516..4655568)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4623667..4639725)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4639528..4655580)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9894 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:4596181-4596372 Neighboring gene Sharpr-MPRA regulatory region 4167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4606740-4607298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4607299-4607856 Neighboring gene MPRA-validated peak3284 silencer Neighboring gene ribosomal protein S10 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4639529-4640528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4660681-4661180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4661482-4662252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9901 Neighboring gene myeloid derived growth factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4675983-4676943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4679601-4680102 Neighboring gene DPP9 antisense RNA 1 Neighboring gene dipeptidyl peptidase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis. Cheng Y, et al. Cancer Res, 2022 Apr 15. PMID 35135809
  2. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells. Bordoloi D, et al. Mol Cell Biochem, 2021 Sep. PMID 33895911
  3. TIPE1 accelerates atherogenesis by inducing endothelial dysfunction in response to oxidative stress. Shao J, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Jan 1. PMID 31672550
  4. TIPE1 suppresses the invasion and migration of breast cancer cells and inhibits epithelial-to-mesenchymal transition primarily via the ERK signaling pathway. Qiu S, et al. Acta Biochim Biophys Sin (Shanghai), 2019 Sep 6. PMID 31559412
  5. TIPE1 promotes cervical cancer progression by repression of p53 acetylation and is associated with poor cervical cancer outcome. Zhao P, et al. Carcinogenesis, 2019 Jun 10. PMID 30445600

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A pan-cancer analysis of TNFAIP8L1 in human tumors.
    Title: A pan-cancer analysis of TNFAIP8L1 in human tumors.
  2. TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/beta-catenin signaling.
    Title: TIPE1 inhibits the growth of Ewing's sarcoma cells by suppressing Wnt/β-catenin signaling.
  3. TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation.
    Title: TIPE1 inhibits osteosarcoma tumorigenesis and progression by regulating PRMT1 mediated STAT3 arginine methylation.
  4. Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFbeta Axis.
    Title: Phosphoinositide-Binding Protein TIPE1 Promotes Alternative Activation of Macrophages and Tumor Progression via PIP3/Akt/TGFβ Axis.
  5. TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
    Title: TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
  6. TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-kappaB pro-oncogenic signaling pathway.
    Title: TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway.
  7. Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells.
    Title: Human tumor necrosis factor alpha-induced protein eight-like 1 exhibited potent anti-tumor effect through modulation of proliferation, survival, migration and invasion of lung cancer cells.
  8. TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.
    Title: TIPE1-mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway.
  9. CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1.
    Title: CDKN3 regulates cisplatin resistance to colorectal cancer through TIPE1.
  10. TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China.
    Title: TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39932, MGC17791

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 1
Names
TNF alpha-induced protein 8-like protein 1
TNFAIP8-like protein 1
oxidative stress-regulated gene-beta
oxy-beta
tumor necrosis factor, alpha induced protein 8 like 1
tumor necrosis factor, alpha-induced protein 8-like protein 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167942.1 → NP_001161414.1  tumor necrosis factor alpha-induced protein 8-like protein 1

    See identical proteins and their annotated locations for NP_001161414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005339, AC011498
    Consensus CDS
    CCDS12132.1
    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5
    Related
    ENSP00000444215.1, ENST00000536716.1
    Conserved Domains (1) summary
    pfam05527
    Location:5 → 183
    DUF758; Domain of unknown function (DUF758)

  2. NM_152362.3 → NP_689575.2  tumor necrosis factor alpha-induced protein 8-like protein 1

    See identical proteins and their annotated locations for NP_689575.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005339, BX282702
    Consensus CDS
    CCDS12132.1
    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5
    Related
    ENSP00000331827.3, ENST00000327473.9
    Conserved Domains (1) summary
    pfam05527
    Location:5 → 183
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4639516..4655568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527680.3 → XP_011525982.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011525982.1

    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5
    Conserved Domains (1) summary
    pfam05527
    Location:5 → 183
    DUF758; Domain of unknown function (DUF758)

  2. XM_005259487.4 → XP_005259544.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005259544.1

    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5
    Conserved Domains (1) summary
    pfam05527
    Location:5 → 183
    DUF758; Domain of unknown function (DUF758)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4623667..4639725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319795.1 → XP_054175770.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5

  2. XM_054319794.1 → XP_054175769.1  tumor necrosis factor alpha-induced protein 8-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D6W627, Q8WVP5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WVP5.2 GenPept UniProtKB/Swiss-Prot:Q8WVP5

Gene LinkOut

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