U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cenpc1 centromere protein C1 [ Mus musculus (house mouse) ]

Gene ID: 12617, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Cenpc1provided by MGI
Official Full Name
centromere protein C1provided by MGI
Primary source
MGI:MGI:99700
See related
Ensembl:ENSMUSG00000029253 AllianceGenome:MGI:99700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cenpc; CENP-C
Summary
This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in CNS E11.5 (RPKM 7.5), CNS E14 (RPKM 5.7) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 E1; 5 43.56 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86159877..86214325, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86012018..86065962, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35251 Neighboring gene STARR-seq mESC enhancer starr_13541 Neighboring gene predicted gene, 24626 Neighboring gene STARR-seq mESC enhancer starr_13543 Neighboring gene STARR-positive B cell enhancer ABC_E1055 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86498237-86498420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86500459-86500642 Neighboring gene STARR-positive B cell enhancer ABC_E3586 Neighboring gene predicted gene 2287 Neighboring gene predicted gene, 24524 Neighboring gene signal transducing adaptor family member 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice. Fan J, et al. J Immunol Res, 2021. PMID 33604391, Free PMC Article
  2. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Kitajima TS, et al. Cell, 2011 Aug 19. PMID 21854982
  3. Targeted disruption of mouse centromere protein C gene leads to mitotic disarray and early embryo death. Kalitsis P, et al. Proc Natl Acad Sci U S A, 1998 Feb 3. PMID 9448298, Free PMC Article
  4. Parallel pathways for recruiting effector proteins determine centromere drive and suppression. Kumon T, et al. Cell, 2021 Sep 16. PMID 34433012, Free PMC Article
  5. The ABCs of CENPs. Perpelescu M, et al. Chromosoma, 2011 Oct. PMID 21751032

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
    Title: Parallel pathways for recruiting effector proteins determine centromere drive and suppression.
  2. Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice.
    Title: Immunization with CENP-C Causes Aberrant Chromosome Segregation during Oocyte Meiosis in Mice.
  3. Further investigation of the phosphoregulation of meiotic Kif4 revealed that Aurora Kinase and Cdk activity is critical for Kif4 kinetochore localization and interaction with Ndc80 and CENP-C. Finally, Kif4 protein but not gene expression was found to be upregulated with age, suggesting a role for this protein in the decline of oocyte quality with age
    Title: Kif4 Is Essential for Mouse Oocyte Meiosis.
  4. CENP-C works as an important factor for centromeric M18BP1 recruitment
    Title: CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables centromeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kinetochore assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle attachment to meiosis I kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
centromere protein C
Names
centromere autoantigen C1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345902.1 → NP_001332831.1  centromere protein C isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6

  2. NM_001345903.1 → NP_001332832.1  centromere protein C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6

  3. NM_001345904.1 → NP_001332833.1  centromere protein C isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6
    Conserved Domains (2) summary
    pfam15620
    Location:2 → 255
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    cl21464
    Location:555 → 639
    cupin_like; Conserved domain found in cupin and related proteins

  4. NM_001421563.1 → NP_001408492.1  centromere protein C isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC101846, AC107634

  5. NM_001421564.1 → NP_001408493.1  centromere protein C isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC101846, AC107634

  6. NM_007683.4 → NP_031709.2  centromere protein C isoform 2

    See identical proteins and their annotated locations for NP_031709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    Consensus CDS
    CCDS39123.1
    UniProtKB/Swiss-Prot
    B9EK81, P49452
    Related
    ENSMUSP00000031170.9, ENSMUST00000031170.10
    Conserved Domains (3) summary
    pfam15620
    Location:266 → 519
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7 → 261
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:819 → 903
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    86159877..86214325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254095.2 → XP_030109955.1  centromere protein C isoform X1

    Conserved Domains (3) summary
    pfam15620
    Location:355 → 608
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:110 → 350
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:889 → 973
    cupin_like; Conserved domain found in cupin and related proteins

  2. XM_017320638.3 → XP_017176127.1  centromere protein C isoform X5

    Conserved Domains (2) summary
    pfam15620
    Location:2 → 255
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    cl21464
    Location:555 → 639
    cupin_like; Conserved domain found in cupin and related proteins

  3. XM_030254096.2 → XP_030109956.1  centromere protein C isoform X2

    Conserved Domains (3) summary
    pfam15620
    Location:355 → 608
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:110 → 350
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:908 → 942
    cupin_like; Conserved domain found in cupin and related proteins

  4. XM_017320636.3 → XP_017176125.1  centromere protein C isoform X3

    Conserved Domains (3) summary
    pfam15620
    Location:266 → 519
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7 → 261
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:819 → 853
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49452.2 GenPept UniProtKB/Swiss-Prot:P49452

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous