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Cebpz CCAAT/enhancer binding protein zeta [ Mus musculus (house mouse) ]

Gene ID: 12607, updated on 5-Mar-2024

Summary

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Official Symbol
Cebpzprovided by MGI
Official Full Name
CCAAT/enhancer binding protein zetaprovided by MGI
Primary source
MGI:MGI:109386
See related
Ensembl:ENSMUSG00000024081 AllianceGenome:MGI:109386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbf; CBF2
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of CCAAT-binding activity factor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; bone; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human CEBPZ (CCAAT enhancer binding protein zeta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 12.2), placenta adult (RPKM 6.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Cebpz in Genome Data Viewer
Location:
17 E3; 17 49.65 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (79226432..79244499, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (78919003..78937070, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 2 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 26637 Neighboring gene sulfotransferase family, cytosolic, 6B, member 1 Neighboring gene STARR-seq mESC enhancer starr_43273 Neighboring gene STARR-positive B cell enhancer ABC_E8698 Neighboring gene CCAAT/enhancer binding protein zeta, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E5629 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene protein kinase D3 Neighboring gene predicted gene, 41622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The CCAAT-binding proteins CP1 and NF-I cooperate with ATF-2 in the transcription of the fibronectin gene. Alonso CR, et al. J Biol Chem, 1996 Sep 6. PMID 8703044
  2. Cloning and characterization of mouse CCAAT binding factor. Hoeppner MA, et al. Nucleic Acids Res, 1996 Mar 15. PMID 8604343, Free PMC Article
  3. The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Paces-Fessy M, et al. Biochem J, 2004 Mar 1. PMID 14611647, Free PMC Article
  4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36087

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCAAT/enhancer-binding protein zeta
Names
CCAAT-binding factor
CCAAT-box-binding transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024806.2 → NP_001019977.1  CCAAT/enhancer-binding protein zeta

    See identical proteins and their annotated locations for NP_001019977.1

    Status: VALIDATED

    Source sequence(s)
    AI848081, AK017537, AK158771, BY077658
    Consensus CDS
    CCDS28981.1
    UniProtKB/Swiss-Prot
    P53569, Q3TXW5, Q3TYA8, Q3UWQ7
    UniProtKB/TrEMBL
    A0A0R4J046
    Related
    ENSMUSP00000024885.9, ENSMUST00000024885.10
    Conserved Domains (3) summary
    COG5593
    Location:179 → 987
    COG5593; Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]
    pfam03914
    Location:523 → 732
    CBF; CBF/Mak21 family
    cl17018
    Location:273 → 436
    FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    79226432..79244499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523558.5 → XP_006523621.1  CCAAT/enhancer-binding protein zeta isoform X1

    Conserved Domains (2) summary
    pfam03914
    Location:1 → 181
    CBF; CBF/Mak21 family
    pfam04147
    Location:275 → 435
    Nop14; Nop14-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009882.2: Suppressed sequence

    Description
    NM_009882.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53569.2 GenPept UniProtKB/Swiss-Prot:P53569

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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