Cebpa CCAAT/enhancer binding protein alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cebpaprovided by MGI
Official Full Name: CCAAT/enhancer binding protein alphaprovided by MGI
Primary source: MGI:MGI:99480
See related: Ensembl:ENSMUSG00000034957 AllianceGenome:MGI:99480
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cebp; CBF-A; C/ebpalpha
Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014]
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.02 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (34818718..34821353)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35119293..35121928)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor C/EBPalpha is required for the development of Ly6C[hi] monocytes but not Ly6C[lo] monocytes.
Title: Transcription factor C/EBPα is required for the development of Ly6C(hi) monocytes but not Ly6C(lo) monocytes.
C/EBPalpha-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
Title: C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation.
Title: An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation.
C/EBPalpha aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
Title: C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
C/EBPalpha alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress via HDAC1-mediated deacetylation of ATF4.
Title: C/EBPα alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress via HDAC1-mediated deacetylation of ATF4.
C/ebpalpha represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development.
Title: C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development.
AIP4 regulates adipocyte differentiation by targeting C/EBPalpha for ubiquitin-mediated proteasomal degradation.
Title: AIP4 regulates adipocyte differentiation by targeting C/EBPα for ubiquitin-mediated proteasomal degradation.
CEBPalpha/miR-101b-3p promotes meningoencephalitis in mice infected with Angiostrongylus cantonensis by promoting microglial pyroptosis.
Title: CEBPα/miR-101b-3p promotes meningoencephalitis in mice infected with Angiostrongylus cantonensis by promoting microglial pyroptosis.
ID1 and CEBPA coordinate epidermal progenitor cell differentiation.
Title: ID1 and CEBPA coordinate epidermal progenitor cell differentiation.
Lipase family member N is a novel target gene for CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse liver.
Title: Lipase family member N is a novel target gene for CCAAT/enhancer-binding protein α in type 2 diabetic model mouse liver.

Submit: New GeneRIF Correction See all GeneRIFs (251)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (21) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cebpa (e-PCR), detects polymorphism
- UniSTS:548130

M62362 (e-PCR)
- UniSTS:124964

BE096629 (e-PCR)
- UniSTS:244045

M62362 (e-PCR)
- UniSTS:179555

NoName (e-PCR)
- UniSTS:235647

Cebpa (e-PCR), detects polymorphism
- UniSTS:516500

RH141409 (e-PCR)
- UniSTS:223404

Cebpa (e-PCR), detects polymorphism
- UniSTS:527283

PMC94247P1 (e-PCR)
- UniSTS:273622

Cebpa (e-PCR), detects polymorphism
- UniSTS:465371

PMC117301P1 (e-PCR)
- UniSTS:270326

PMC117301P2 (e-PCR)
- UniSTS:270327

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase I transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryonic placenta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in granulocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urea cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of C/EBP complex	ISO Inferred from Sequence Orthology more info
part_of CHOP-C/EBP complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of Rb-E2F complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CCAAT/enhancer-binding protein alpha

Names: C/EBP alpha; CCAAT/enhancer binding protein (C/EBP), alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287514.1 → NP_001274443.1 CCAAT/enhancer-binding protein alpha isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from four downstream, in-frame AUG sites. The isoform (c, also known as extended) represented in this RefSeq results from translation initiation at the upstream CUG start codon. Isoform c is the longest isoform.

Source sequence(s)

AC150683

UniProtKB/TrEMBL

Q3U2H8

Conserved Domains (1) summary

cd14711
Location:318 → 378

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
NM_001287515.1 → NP_001274444.1 CCAAT/enhancer-binding protein alpha isoform d

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from four downstream, in-frame AUG sites. The isoform (d, also known as 35-kDa) represented in this RefSeq results from translation initiation at the second AUG start codon. Isoform d has a shorter N-terminus, compared to isoform c.

Source sequence(s)

AC150683

UniProtKB/TrEMBL

Q3U2H8

Conserved Domains (1) summary

cd14711
Location:267 → 327

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
NM_001287521.1 → NP_001274450.1 CCAAT/enhancer-binding protein alpha isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from four downstream, in-frame AUG sites. The isoform (b, also known as 30-kDa) represented in this RefSeq results from translation initiation at the third AUG start codon. Isoform b has a shorter N-terminus, compared to isoform c.

Source sequence(s)

AC150683

UniProtKB/Swiss-Prot

P53566

Conserved Domains (1) summary

cd14711
Location:164 → 224

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
NM_001287523.1 → NP_001274452.1 CCAAT/enhancer-binding protein alpha isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from four downstream, in-frame AUG sites. The isoform (e, also known as 20-kDa) represented in this RefSeq results from translation initiation at the fourth AUG start codon. Isoform e has a shorter N-terminus, compared to isoform c.

Source sequence(s)

AC150683

Conserved Domains (1) summary

cd14711
Location:68 → 128

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain
NM_007678.4 → NP_031704.2 CCAAT/enhancer-binding protein alpha isoform a

See identical proteins and their annotated locations for NP_031704.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from an upstream non-AUG (CUG) site, and also from four downstream, in-frame AUG sites. The isoform (a, also known as 42-kDa) represented in this RefSeq results from translation initiation at the first AUG start codon. Isoform a has a shorter N-terminus, compared to isoform c.

Source sequence(s)

AC150683

Consensus CDS

CCDS21145.1

UniProtKB/Swiss-Prot

P53566, Q91XB6

UniProtKB/TrEMBL

Q3U2H8

Related

ENSMUSP00000096129.5, ENSMUST00000042985.11

Conserved Domains (1) summary

cd14711
Location:281 → 341

bZIP_CEBPA; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein alpha (CEBPA): a DNA-binding and dimerization domain