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Cdr2 cerebellar degeneration-related 2 [ Mus musculus (house mouse) ]

Gene ID: 12585, updated on 5-Mar-2024

Summary

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Official Symbol
Cdr2provided by MGI
Official Full Name
cerebellar degeneration-related 2provided by MGI
Primary source
MGI:MGI:1100885
See related
Ensembl:ENSMUSG00000030878 AllianceGenome:MGI:1100885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Located in cytoplasm. Is expressed in central nervous system; liver lobe; and retina. Orthologous to human CDR2 (cerebellar degeneration related protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 62.2), liver E14.5 (RPKM 61.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2; 7 65.04 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120556259..120581535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120957036..120982312, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene polymerase (RNA) III (DNA directed) polypeptide E Neighboring gene STARR-positive B cell enhancer ABC_E450 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene predicted pseudogene 9234 Neighboring gene predicted gene, 25924

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy. Blachère NE, et al. JCI Insight, 2017 Nov 2. PMID 29093272, Free PMC Article
  2. A post-transcriptional regulatory mechanism restricts expression of the paraneoplastic cerebellar degeneration antigen cdr2 to immune privileged tissues. Corradi JP, et al. J Neurosci, 1997 Feb 15. PMID 9006982, Free PMC Article
  3. The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival. Okano HJ, et al. Genes Dev, 1999 Aug 15. PMID 10465786, Free PMC Article
  4. Diversification of stem cell molecular repertoire by alternative splicing. Pritsker M, et al. Proc Natl Acad Sci U S A, 2005 Oct 4. PMID 16183747, Free PMC Article
  5. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Fletcher CF, et al. Genomics, 1997 Oct 15. PMID 9344654

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144810, MGC144811

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cerebellar degeneration-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354986.1 → NP_001341915.1  cerebellar degeneration-related protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122248

  2. NM_007672.2 → NP_031698.2  cerebellar degeneration-related protein 2 isoform 1

    See identical proteins and their annotated locations for NP_031698.2

    Status: VALIDATED

    Source sequence(s)
    BC117530, BX637405, BY713743, CF616011, DT902919
    Consensus CDS
    CCDS21798.1
    UniProtKB/Swiss-Prot
    P97817, Q3UG92
    UniProtKB/TrEMBL
    Q3TAP7
    Related
    ENSMUSP00000033169.9, ENSMUST00000033169.9
    Conserved Domains (1) summary
    TIGR02168
    Location:19 → 262
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    120556259..120581535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97817.2 GenPept UniProtKB/Swiss-Prot:P97817

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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