Cdkn2d cyclin dependent kinase inhibitor 2D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdkn2dprovided by MGI
Official Full Name: cyclin dependent kinase inhibitor 2Dprovided by MGI
Primary source: MGI:MGI:105387
See related: Ensembl:ENSMUSG00000096472 AllianceGenome:MGI:105387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p19; INK4d; p19INK4d
Summary: Enables protein kinase binding activity. Acts upstream of or within negative regulation of cell cycle G1/S phase transition and sensory perception of sound. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including central nervous system; genitourinary system; liver lobe; retina; and trigeminal nerve. Orthologous to human CDKN2D (cyclin dependent kinase inhibitor 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 73.0), liver E14.5 (RPKM 39.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.76 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (21199759..21202553, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (21288459..21291421, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor.
Title: p19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor.
The expression of three tumor suppressor genes encoded in the INK4/ARF locus (p15(INK4b), p16(INK4a), and p19(ARF)) was decreased in E6AP(-/-) embryo fibroblasts.
Title: Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
TWIST1-E protein heterodimeric complexes may thus constitute the main active forms of TWIST1 with regard to senescence inhibition over the time course of breast tumorigenesis.
Title: p53 and p16(Ink4a)/p19(Arf) Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor Cells.
Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
Title: Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d.
p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging
Title: p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.
Cdk4 and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4.
Title: Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase CDK inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues.
Title: p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation.
We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction
Title: p19INK4d is involved in the cellular senescence mechanism contributing to heterochromatin formation.
CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
Title: CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions.
an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos.
Title: Differential expression of Axin1, Cdc25c and Cdkn2d mRNA in 2-cell stage mouse blastomeres.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA synthesis involved in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in autophagic cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell cycle G1/S phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin D	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin D2-CDK4 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase 4 inhibitor D

Names: cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); p19-INK4d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409664.1 → NP_001396593.1 cyclin-dependent kinase 4 inhibitor D isoform 1

Status: VALIDATED

Source sequence(s)

AC122525

UniProtKB/Swiss-Prot

Q60773, Q60794, Q91YV3

Related

ENSMUSP00000149499.2, ENSMUST00000213407.2
NM_001409665.1 → NP_001396594.1 cyclin-dependent kinase 4 inhibitor D isoform 2

Status: VALIDATED

Source sequence(s)

AC122525
NM_001409666.1 → NP_001396595.1 cyclin-dependent kinase 4 inhibitor D isoform 2

Status: VALIDATED

Source sequence(s)

AC122525
NM_009878.4 → NP_034008.2 cyclin-dependent kinase 4 inhibitor D isoform 1

See identical proteins and their annotated locations for NP_034008.2

Status: VALIDATED

Source sequence(s)

AC122525

Consensus CDS

CCDS22901.1

UniProtKB/Swiss-Prot

Q60773, Q60794, Q91YV3

UniProtKB/TrEMBL

A0A1L1SRJ2

Related

ENSMUSP00000150701.2, ENSMUST00000215619.2

Conserved Domains (3) summary

PLN03192
Location:9 → 66

PLN03192; Voltage-dependent potassium channel; Provisional

sd00045
Location:41 → 71

ANK; ANK repeat [structural motif]

pfam12796
Location:50 → 136

Ank_2; Ankyrin repeats (3 copies)