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Cdh8 cadherin 8 [ Mus musculus (house mouse) ]

Gene ID: 12564, updated on 21-Apr-2024

Summary

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Official Symbol
Cdh8provided by MGI
Official Full Name
cadherin 8provided by MGI
Primary source
MGI:MGI:107434
See related
Ensembl:ENSMUSG00000036510 AllianceGenome:MGI:107434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cad8
Summary
This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
Expression
Biased expression in CNS E18 (RPKM 7.5), whole brain E14.5 (RPKM 4.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D1; 8 49.4 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (99751103..100144298, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (99024471..99417666, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22444 Neighboring gene STARR-seq mESC enhancer starr_22445 Neighboring gene predicted gene, 23494 Neighboring gene STARR-seq mESC enhancer starr_22446 Neighboring gene STARR-seq mESC enhancer starr_22447 Neighboring gene STARR-seq mESC enhancer starr_22448 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-seq mESC enhancer starr_22449 Neighboring gene predicted gene 15679 Neighboring gene predicted gene, 24693 Neighboring gene protein phosphatase 4, regulatory subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22450 Neighboring gene STARR-seq mESC enhancer starr_22451 Neighboring gene RIKEN cDNA A330008L17 gene Neighboring gene STARR-seq mESC enhancer starr_22453 Neighboring gene STARR-seq mESC enhancer starr_22454 Neighboring gene STARR-seq mESC enhancer starr_22455 Neighboring gene STARR-seq mESC enhancer starr_22456 Neighboring gene STARR-seq mESC enhancer starr_22457 Neighboring gene STARR-seq mESC enhancer starr_22458 Neighboring gene STARR-seq mESC enhancer starr_22459 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22461 Neighboring gene inosine monophosphate dehydrogenase 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. Friedman LG, et al. J Comp Neurol, 2015 Jan 1. PMID 25158904, Free PMC Article
  2. Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. Miloushev VZ, et al. Structure, 2008 Aug 6. PMID 18682221, Free PMC Article
  3. Cortical area size dictates performance at modality-specific behaviors. Leingärtner A, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360492, Free PMC Article
  4. Expression of cadherin-8 mRNA in the developing mouse central nervous system. Korematsu K, et al. J Comp Neurol, 1997 Oct 20. PMID 9336230
  5. Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. Suzuki SC, et al. J Neurosci, 2007 Mar 28. PMID 17392463, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The autism-associated protein CHD8 is required for cerebellar development and motor function.
    Title: The autism-associated protein CHD8 is required for cerebellar development and motor function.
  2. Cdh8 has role in neurogenesis in the ventral telencephalon during development.
    Title: Cadherin 8 regulates proliferation of cortical interneuron progenitors.
  3. Results indicate that Cdh8 delineates developing corticostriatal circuits where it is a strong candidate for regulating the generation of normal cortical projections, neuronal morphology, and corticostriatal synapses
    Title: Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
  4. Study shows that bipolar cells BC2s and BC5s deliver visual input to neurons that compute direction of motion and demonstrate that Cdh8 and Cdh9 are required for assembly of the circuit.
    Title: Type II cadherins guide assembly of a direction-selective retinal circuit.
  5. Results describe individual monomer and dimer states and the monomer-dimer equilibrium of the mouse Type II cadherin-8 EC1 domain.
    Title: Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.
  6. These results demonstrate that cad8 is essential for establishing the physiological coupling between cold-sensitive sensory neurons and their target DH neurons.
    Title: Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cadherin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039154.2 → NP_001034243.1  cadherin-8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001034243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region that leads to a frameshift compared to variant 2. The resulting protein (isoform 1) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AC103397, BC057581, BU058167
    Consensus CDS
    CCDS22569.1
    UniProtKB/TrEMBL
    Q8C375, Q8C449
    Related
    ENSMUSP00000090935.5, ENSMUST00000093249.11
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:653 → 708
    Cadherin_C; Cadherin cytoplasmic region

  2. NM_001285913.1 → NP_001272842.1  cadherin-8 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (3) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AK044046, AK139334, BC057581, BU058167
    Consensus CDS
    CCDS72155.1
    UniProtKB/TrEMBL
    E9Q451, Q8BRK4
    Related
    ENSMUSP00000123619.2, ENSMUST00000155527.8
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:653 → 711
    Cadherin_C; Cadherin cytoplasmic region

  3. NM_001285914.1 → NP_001272843.1  cadherin-8 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (4) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AK044046, AK139334, BC057581, BU058167
    Consensus CDS
    CCDS72156.1
    UniProtKB/TrEMBL
    E9PYB2, Q3UTL9
    Related
    ENSMUSP00000114507.2, ENSMUST00000142129.8
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:653 → 701
    Cadherin_C; Cadherin cytoplasmic region

  4. NM_007667.3 → NP_031693.2  cadherin-8 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_031693.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 2).
    Source sequence(s)
    AC103397, BC057581, BU058167
    Consensus CDS
    CCDS40448.1
    UniProtKB/Swiss-Prot
    G3UVU4, P97291
    UniProtKB/TrEMBL
    Q3UTL9
    Related
    ENSMUSP00000117326.2, ENSMUST00000128860.8
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:645 → 790
    Cadherin_C; Cadherin cytoplasmic region

RNA

  1. NR_133570.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' terminus, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC102643, AC103397, BC060200, BU058167
    Related
    ENSMUST00000145601.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    99751103..100144298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243274.1 → XP_030099134.1  cadherin-8 isoform X1

    UniProtKB/Swiss-Prot
    G3UVU4, P97291
    UniProtKB/TrEMBL
    Q3UTL9
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:645 → 790
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_017312551.3 → XP_017168040.1  cadherin-8 isoform X3

    Conserved Domains (2) summary
    smart00112
    Location:17 → 55
    CA; Cadherin repeats
    pfam01049
    Location:98 → 243
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_006530631.3 → XP_006530694.1  cadherin-8 isoform X1

    See identical proteins and their annotated locations for XP_006530694.1

    UniProtKB/Swiss-Prot
    G3UVU4, P97291
    UniProtKB/TrEMBL
    Q3UTL9
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:645 → 790
    Cadherin_C; Cadherin cytoplasmic region

  4. XM_006530634.5 → XP_006530697.1  cadherin-8 isoform X2

    UniProtKB/TrEMBL
    Q8BRK4
    Conserved Domains (3) summary
    cd11304
    Location:281 → 387
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:87 → 165
    CA; Cadherin repeats
    pfam01049
    Location:645 → 700
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97291.2 GenPept UniProtKB/Swiss-Prot:P97291

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