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Cdh11 cadherin 11 [ Mus musculus (house mouse) ]

Gene ID: 12552, updated on 11-Apr-2024

Summary

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Official Symbol
Cdh11provided by MGI
Official Full Name
cadherin 11provided by MGI
Primary source
MGI:MGI:99217
See related
Ensembl:ENSMUSG00000031673 AllianceGenome:MGI:99217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cad11; OSF-4
Summary
This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
Expression
Biased expression in limb E14.5 (RPKM 39.5), CNS E11.5 (RPKM 18.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D1; 8 50.44 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (103358727..103512125, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (102632095..102785493, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene myotubularin-related protein 12 pseudogene Neighboring gene predicted gene, 39233 Neighboring gene STARR-seq mESC enhancer starr_22482 Neighboring gene STARR-seq mESC enhancer starr_22483 Neighboring gene STARR-seq mESC enhancer starr_22484 Neighboring gene STARR-seq mESC enhancer starr_22485 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene VISTA enhancer mm40 Neighboring gene STARR-seq mESC enhancer starr_22486 Neighboring gene predicted gene, 32531

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cadherin-11 Regulates Macrophage Development and Function. To S, et al. Front Immunol, 2022. PMID 35211116, Free PMC Article
  2. Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response. Johnson CL, et al. Am J Physiol Heart Circ Physiol, 2021 Oct 1. PMID 34506228, Free PMC Article
  3. Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping. Koss H, et al. Structure, 2021 Oct 7. PMID 34166612, Free PMC Article
  4. Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11. Johnson CL, et al. J Biomech, 2021 Apr 15. PMID 33636459, Free PMC Article
  5. Cadherin-11 binds to PDGFRβ and enhances cell proliferation and tissue regeneration via the PDGFR-AKT signaling axis. Liu Y, et al. FASEB J, 2020 Mar. PMID 31930567

See all (137) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cadherin-11 and Its Role in Tissue Fibrosis.
    Title: Cadherin-11 and Its Role in Tissue Fibrosis.
  2. Cadherin-11 Regulates Macrophage Development and Function.
    Title: Cadherin-11 Regulates Macrophage Development and Function.
  3. Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping.
    Title: Dimerization of Cadherin-11 involves multi-site coupled unfolding and strand swapping.
  4. Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.
    Title: Association of CDH11 with Autism Spectrum Disorder Revealed by Matched-gene Co-expression Analysis and Mouse Behavioral Studies.
  5. Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.
    Title: Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response.
  6. Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
    Title: Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism.
  7. Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
    Title: Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.
  8. Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.
    Title: Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.
  9. Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction.
    Title: Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction.
  10. mRNA expression profiles of two autism spectrum disorder-associated cadherins, Cdh9 and Cdh11, in the developing cerebellum, were examined.
    Title: Segregated expressions of autism risk genes Cdh11 and Cdh9 in autism-relevant regions of developing cerebellum.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25339

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within corticospinal tract morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cadherin-11
Names
OB-cadherin
osteoblast cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416447.1 → NP_001403376.1  cadherin-11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC105256, AC141869
    UniProtKB/Swiss-Prot
    P55288

  2. NM_009866.6 → NP_033996.4  cadherin-11 preproprotein

    See identical proteins and their annotated locations for NP_033996.4

    Status: VALIDATED

    Source sequence(s)
    AC105256, AC141869
    Consensus CDS
    CCDS22571.1
    UniProtKB/Swiss-Prot
    P55288
    UniProtKB/TrEMBL
    Q8C7Q6
    Related
    ENSMUSP00000074681.4, ENSMUST00000075190.5
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:641 → 789
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    103358727..103512125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530624.3 → XP_006530687.1  cadherin-11 isoform X1

    See identical proteins and their annotated locations for XP_006530687.1

    UniProtKB/Swiss-Prot
    P55288
    UniProtKB/TrEMBL
    Q8C7Q6
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:641 → 789
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_030243272.2 → XP_030099132.1  cadherin-11 isoform X1

    UniProtKB/Swiss-Prot
    P55288
    UniProtKB/TrEMBL
    Q8C7Q6
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:641 → 789
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55288.1 GenPept UniProtKB/Swiss-Prot:P55288

Gene LinkOut

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