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Cd82 CD82 antigen [ Mus musculus (house mouse) ]

Gene ID: 12521, updated on 11-Apr-2024

Summary

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Official Symbol
Cd82provided by MGI
Official Full Name
CD82 antigenprovided by MGI
Primary source
MGI:MGI:104651
See related
Ensembl:ENSMUSG00000027215 AllianceGenome:MGI:104651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C33; IA4; Kai1; Tspan27
Summary
Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including choroid plexus; foregut; limb segment; meninges; and olfactory epithelium. Orthologous to human CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 142.7), duodenum adult (RPKM 91.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Cd82 in Genome Data Viewer
Location:
2 E1; 2 51.62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (93249447..93293295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (93419102..93462950, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32745 Neighboring gene predicted gene 13807 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93264860-93264969 Neighboring gene STARR-positive B cell enhancer ABC_E5946 Neighboring gene microRNA 7001 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:93299170-93299353 Neighboring gene STARR-positive B cell enhancer ABC_E2630 Neighboring gene STARR-positive B cell enhancer ABC_E4482 Neighboring gene predicted gene 10804 Neighboring gene predicted gene, 54115 Neighboring gene predicted gene, 33010

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation. McGowan ENS, et al. iScience, 2022 Jul 15. PMID 35754722, Free PMC Article
  2. Tetraspanin CD82 regulates S1PR(1)-mediated hematopoietic stem and progenitor cell mobilization. Saito-Reis CA, et al. Stem Cell Reports, 2021 Oct 12. PMID 34534447, Free PMC Article
  3. KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state. Lee JW, et al. J Hematol Oncol, 2021 Sep 16. PMID 34530889, Free PMC Article
  4. Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Hall A, et al. Skelet Muscle, 2020 Nov 27. PMID 33243288, Free PMC Article
  5. The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells. Saito-Reis CA, et al. Mol Biol Cell, 2018 Nov 26. PMID 30133344, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
    Title: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
  2. Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and progenitor cell mobilization.
    Title: Tetraspanin CD82 regulates S1PR(1)-mediated hematopoietic stem and progenitor cell mobilization.
  3. KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.
    Title: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.
  4. Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.
    Title: Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.
  5. CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
    Title: CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
  6. study demonstrates that CD82 is a specific regulator of TLR9 signaling, which may be critical in cancer immunotherapy approaches and coordinating the innate immune response to pathogens.
    Title: CD82 controls CpG-dependent TLR9 signaling.
  7. these data demonstrate that CD82 organizes the proper assembly of Dectin-1 signaling machinery in response to Candida albicans
    Title: Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.
  8. Data provide evidence that CD82 is an important regulator of HSPC bone marrow maintenance, homing, and engraftment.
    Title: The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells.
  9. Loss of CD82 resulted in defects in osteoclast, osteoblast, and adipocyte lineages.
    Title: Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.
  10. CD82-RUNX1-Rab5/22 axis may be a previously unrecognized virulence mechanism of Mycobacterium tuberculosis pathogenesis.
    Title: CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CD82 antigen
Names
C33 antigen
inducible membrane protein R2
kangai 1 (suppression of tumorigenicity 6, prostate)
metastasis suppressor Kangai-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136055.2 → NP_001129527.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001129527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AK135381, AL732483, BM215013
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Related
    ENSMUSP00000112158.3, ENSMUST00000116457.9
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  2. NM_001271430.1 → NP_001258359.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001258359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AK135381, AK160907, AL732483, BM215013
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Related
    ENSMUSP00000097287.2, ENSMUST00000099696.8
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. NM_001271431.1 → NP_001258360.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001258360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AL732483
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  4. NM_001271432.1 → NP_001258361.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001258361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AL732483
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  5. NM_001271461.1 → NP_001258390.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001258390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AL732483
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  6. NM_001271462.1 → NP_001258391.1  CD82 antigen

    See identical proteins and their annotated locations for NP_001258391.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AL732483
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Related
    ENSMUSP00000106888.2, ENSMUST00000111257.8
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  7. NM_007656.5 → NP_031682.1  CD82 antigen

    See identical proteins and their annotated locations for NP_031682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AL732483
    Consensus CDS
    CCDS16454.1
    UniProtKB/Swiss-Prot
    P40237
    UniProtKB/TrEMBL
    Q3UII2
    Related
    ENSMUSP00000028644.5, ENSMUST00000028644.11
    Conserved Domains (1) summary
    cd03160
    Location:106 → 228
    CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    93249447..93293295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40237.1 GenPept UniProtKB/Swiss-Prot:P40237

Gene LinkOut

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