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Entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Mus musculus (house mouse) ]

Gene ID: 12497, updated on 11-Apr-2024

Summary

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Official Symbol
Entpd6provided by MGI
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 6provided by MGI
Primary source
MGI:MGI:1202295
See related
Ensembl:ENSMUSG00000033068 AllianceGenome:MGI:1202295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd39l2; NTPDase-6; 2700026H11Rik
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process; response to calcium ion; and response to magnesium ion. Predicted to be located in cell surface; extracellular space; and plasma membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 27.5), genital fat pad adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 74.74 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150590959..150613595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150748980..150771675)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene RIKEN cDNA E130215H24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4509 Neighboring gene STARR-seq mESC enhancer starr_06014 Neighboring gene visual system homeobox 1 Neighboring gene STARR-positive B cell enhancer ABC_E2053 Neighboring gene STARR-positive B cell enhancer ABC_E1604 Neighboring gene STARR-positive B cell enhancer ABC_E11166 Neighboring gene predicted gene, 30141 Neighboring gene predicted gene, 57834 Neighboring gene brain glycogen phosphorylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases. Chadwick BP, et al. Mamm Genome, 1998 Feb. PMID 9457681
  2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Chadwick BP, et al. Genomics, 1998 Jun 15. PMID 9676430
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables IDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside triphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to magnesium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 6
Names
CD39 antigen-like 2
NTPDase 6
NP_001341997.1
NP_001357558.1
NP_001357559.1
NP_001357560.1
NP_742115.2
XP_017170703.1
XP_030102887.1
XP_030102889.1
XP_030102891.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355068.1 → NP_001341997.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845174
    Consensus CDS
    CCDS16861.1
    UniProtKB/Swiss-Prot
    Q3U0P5
    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. NM_001370629.1 → NP_001357558.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845174
    Conserved Domains (1) summary
    cl17037
    Location:71 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. NM_001370630.1 → NP_001357559.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL845174
    Conserved Domains (1) summary
    cl17037
    Location:71 → 424
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. NM_001370631.1 → NP_001357560.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL845174
    Conserved Domains (1) summary
    cl17037
    Location:71 → 207
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. NM_172117.5 → NP_742115.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

    See identical proteins and their annotated locations for NP_742115.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845174
    Consensus CDS
    CCDS16861.1
    UniProtKB/Swiss-Prot
    Q3U0P5
    Related
    ENSMUSP00000092038.6, ENSMUST00000094467.6
    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    150590959..150613595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247031.2 → XP_030102891.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:1 → 228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_017315214.3 → XP_017170703.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:1 → 228
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_030247029.1 → XP_030102889.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0P5
    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_030247027.2 → XP_030102887.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q3U0P5
    Conserved Domains (1) summary
    cl17037
    Location:71 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RNA

  1. XR_003950191.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U0P5.1 GenPept UniProtKB/Swiss-Prot:Q3U0P5

Gene LinkOut

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