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Cd151 CD151 antigen [ Mus musculus (house mouse) ]

Gene ID: 12476, updated on 11-Apr-2024

Summary

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Official Symbol
Cd151provided by MGI
Official Full Name
CD151 antigenprovided by MGI
Primary source
MGI:MGI:1096360
See related
Ensembl:ENSMUSG00000025510 AllianceGenome:MGI:1096360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SFA-1; PETA-3; Tspan24
Summary
Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be integral component of plasma membrane. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 306.7), ovary adult (RPKM 269.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Cd151 in Genome Data Viewer
Location:
7 F5; 7 86.82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141047275..141051394)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141467362..141471481)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling. Li H, et al. Neoplasia, 2019 Dec. PMID 31783316, Free PMC Article
  2. CD151, a novel host factor of nuclear export signaling in influenza virus infection. Qiao Y, et al. J Allergy Clin Immunol, 2018 May. PMID 29274410
  3. Characterization of the early molecular changes in the glomeruli of Cd151 (-/-) mice highlights induction of mindin and MMP-10. Naudin C, et al. Sci Rep, 2017 Nov 22. PMID 29167507, Free PMC Article
  4. CD151 represses mammary gland development by maintaining the niches of progenitor cells. Yin Y, et al. Cell Cycle, 2014. PMID 25486358, Free PMC Article
  5. Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model. Roselli S, et al. BMC Cancer, 2014 Jul 11. PMID 25012362, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes.
    Title: miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
  2. our study suggests that CD151 is a key player in the Wnt oncogene-driven tumorigenesis and impacts breast cancer malignancy in a cell type-dependent manner.
    Title: Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling.
  3. CD151 is a critical novel host factor of nuclear export signaling.
    Title: CD151, a novel host factor of nuclear export signaling in influenza virus infection.
  4. in complex with P2Y12 receptor contributes to thrombus growth and stability
    Title: A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
  5. Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
    Title: Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
  6. Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program.
    Title: CD151 represses mammary gland development by maintaining the niches of progenitor cells.
  7. Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes.
    Title: Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.
  8. We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis.
    Title: Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.
  9. Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma.
    Title: Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.
  10. study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (and EGFR) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis
    Title: Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CD151 antigen
Names
GP27
membrane glycoprotein SFA-1
platelet-endothelial tetraspan antigen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111049.1 → NP_001104519.1  CD151 antigen

    See identical proteins and their annotated locations for NP_001104519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI155754, AW539552, BQ896459, DV063036, U89772
    Consensus CDS
    CCDS22017.1
    UniProtKB/Swiss-Prot
    O35566, O89118
    UniProtKB/TrEMBL
    Q921J7
    Related
    ENSMUSP00000136331.2, ENSMUST00000177840.9
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:15 → 248
    Tetraspannin; Tetraspanin family

  2. NM_001111050.1 → NP_001104520.1  CD151 antigen

    See identical proteins and their annotated locations for NP_001104520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI155754, AW539552, CJ066904, U89772
    Consensus CDS
    CCDS22017.1
    UniProtKB/Swiss-Prot
    O35566, O89118
    UniProtKB/TrEMBL
    Q921J7
    Related
    ENSMUSP00000061636.6, ENSMUST00000058746.7
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:15 → 248
    Tetraspannin; Tetraspanin family

  3. NM_009842.3 → NP_033972.2  CD151 antigen

    See identical proteins and their annotated locations for NP_033972.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI155754, AW539552, BQ896459, D89290, U89772
    Consensus CDS
    CCDS22017.1
    UniProtKB/Swiss-Prot
    O35566, O89118
    UniProtKB/TrEMBL
    Q921J7
    Related
    ENSMUSP00000101622.3, ENSMUST00000106000.10
    Conserved Domains (2) summary
    cd03155
    Location:112 → 220
    CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:15 → 248
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141047275..141051394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35566.2 GenPept UniProtKB/Swiss-Prot:O35566

Gene LinkOut

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