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Cct2 chaperonin containing TCP1 subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 12461, updated on 11-Apr-2024

Summary

Official Symbol
Cct2provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 2provided by MGI
Primary source
MGI:MGI:107186
See related
Ensembl:ENSMUSG00000034024 AllianceGenome:MGI:107186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cctb
Summary
Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in brain; nasal process; neural tube; somite; and telencephalon. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 94.1), placenta adult (RPKM 81.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cct2 in Genome Data Viewer
Location:
10 D2; 10 65.07 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116886902..116899757, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117050997..117063852, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10747 Neighboring gene leucine rich repeat containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2966 Neighboring gene STARR-positive B cell enhancer ABC_E8366 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene STARR-seq mESC enhancer starr_27971 Neighboring gene predicted gene, 40811 Neighboring gene predicted gene, 53635

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit beta
Names
CCT-beta
TCP-1-beta
chaperonin containing Tcp1, subunit 2 (beta)
chaperonin subunit 2 (beta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358767.1NP_001345696.1  T-complex protein 1 subunit beta

    Status: VALIDATED

    Source sequence(s)
    AK145406, BU755483, BY075050, CJ076140
    UniProtKB/Swiss-Prot
    P80314, Q9R1U0
    UniProtKB/TrEMBL
    Q542X7, Q9JJD8
    Conserved Domains (1) summary
    cd03336
    Location:11527
    TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
  2. NM_007636.3NP_031662.2  T-complex protein 1 subunit beta

    See identical proteins and their annotated locations for NP_031662.2

    Status: VALIDATED

    Source sequence(s)
    AK145406, AL589661, BU755483
    Consensus CDS
    CCDS36067.1
    UniProtKB/Swiss-Prot
    P80314, Q9R1U0
    UniProtKB/TrEMBL
    Q542X7, Q9JJD8
    Related
    ENSMUSP00000036288.8, ENSMUST00000047672.9
    Conserved Domains (1) summary
    cd03336
    Location:11527
    TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    116886902..116899757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)