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KIF19 kinesin family member 19 [ Homo sapiens (human) ]

Gene ID: 124602, updated on 7-Apr-2024

Summary

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Official Symbol
KIF19provided by HGNC
Official Full Name
kinesin family member 19provided by HGNC
Primary source
HGNC:HGNC:26735
See related
Ensembl:ENSG00000196169 MIM:619610; AllianceGenome:HGNC:26735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF19A
Summary
Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Predicted to be involved in axonemal microtubule depolymerization; microtubule-based movement; and plus-end specific microtubule depolymerization. Predicted to be located in cilium. Predicted to be part of kinesin complex. Predicted to be active in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 3.3), duodenum (RPKM 1.5) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See KIF19 in Genome Data Viewer
Location:
17q25.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74326226..74355820)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75216872..75246454)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72322365..72351959)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72220111-72220644 Neighboring gene tweety family member 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72241021-72241915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72280764-72281359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72285237-72285737 Neighboring gene dynein axonemal intermediate chain 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:72292700-72292934 Neighboring gene uncharacterized LOC105371891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8928 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:72324530-72325444 Neighboring gene Sharpr-MPRA regulatory region 11842 Neighboring gene uncharacterized LOC107985078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72348389-72348919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72353094-72353966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8929 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72364259-72365247 Neighboring gene BTB domain containing 17 Neighboring gene G protein-coupled receptor 142

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
  3. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. Yang JS, et al. Nat Commun, 2018 Sep 14. PMID 30217970, Free PMC Article
  4. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axonemal microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plus-end specific microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153209.4 → NP_694941.2  kinesin-like protein KIF19

    See identical proteins and their annotated locations for NP_694941.2

    Status: VALIDATED

    Source sequence(s)
    AA527573, AC103809, AW014742, AW339468, BC110989, BE219924, DA955730
    Consensus CDS
    CCDS32718.2
    UniProtKB/Swiss-Prot
    A6NLG2, B7ZKR1, Q2TAC6, Q52M87, Q8N1X8, Q8TAB6
    Related
    ENSP00000374566.4, ENST00000389916.5
    Conserved Domains (2) summary
    smart00129
    Location:14 → 353
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:11 → 346
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74326226..74355820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024150.2 → XP_016879639.1  kinesin-like protein KIF19 isoform X1

  2. XM_017024151.2 → XP_016879640.1  kinesin-like protein KIF19 isoform X2

  3. XM_005257029.2 → XP_005257086.1  kinesin-like protein KIF19 isoform X3

    Conserved Domains (2) summary
    smart00129
    Location:14 → 353
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:11 → 346
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  4. XM_017024152.2 → XP_016879641.1  kinesin-like protein KIF19 isoform X4

  5. XM_017024153.2 → XP_016879642.1  kinesin-like protein KIF19 isoform X5

  6. XM_005257030.2 → XP_005257087.1  kinesin-like protein KIF19 isoform X6

    Conserved Domains (2) summary
    smart00129
    Location:14 → 311
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:11 → 304
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

  7. XM_017024154.2 → XP_016879643.1  kinesin-like protein KIF19 isoform X7

  8. XM_047435317.1 → XP_047291273.1  kinesin-like protein KIF19 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75216872..75246454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314995.1 → XP_054170970.1  kinesin-like protein KIF19 isoform X1

  2. XM_054314996.1 → XP_054170971.1  kinesin-like protein KIF19 isoform X2

  3. XM_054314997.1 → XP_054170972.1  kinesin-like protein KIF19 isoform X3

  4. XM_054314998.1 → XP_054170973.1  kinesin-like protein KIF19 isoform X4

  5. XM_054314999.1 → XP_054170974.1  kinesin-like protein KIF19 isoform X5

  6. XM_054315000.1 → XP_054170975.1  kinesin-like protein KIF19 isoform X6

  7. XM_054315001.1 → XP_054170976.1  kinesin-like protein KIF19 isoform X7

  8. XM_054315002.1 → XP_054170977.1  kinesin-like protein KIF19 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TAC6.2 GenPept UniProtKB/Swiss-Prot:Q2TAC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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