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Ccni cyclin I [ Mus musculus (house mouse) ]

Gene ID: 12453, updated on 3-Apr-2024

Summary

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Official Symbol
Ccniprovided by MGI
Official Full Name
cyclin Iprovided by MGI
Primary source
MGI:MGI:1341077
See related
Ensembl:ENSMUSG00000063015 AllianceGenome:MGI:1341077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within regulation of cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebellum and retina layer. Orthologous to human CCNI (cyclin I). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 56.6), colon adult (RPKM 53.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E2; 5 47.29 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (93329796..93354348, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (93181933..93206495, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22915 Neighboring gene septin 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93522357-93522466 Neighboring gene STARR-seq mESC enhancer starr_13664 Neighboring gene VISTA enhancer mm39 Neighboring gene RIKEN cDNA 2010109A12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:93635715-93635902 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene predicted gene, 42116

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo expression and genomic organization of the mouse cyclin I gene (Ccni). Jensen MR, et al. Gene, 2000 Oct 3. PMID 11054536
  2. Assignment of the cyclin I gene (Ccni) to mouse chromosome 5E3.3-F1. 3 by in situ hybridization. Jensen MR, et al. Cytogenet Cell Genet, 1998. PMID 10072591
  3. Cyclin I and p35 determine the subcellular distribution of Cdk5. Hagmann H, et al. Am J Physiol Cell Physiol, 2015 Feb 15. PMID 25500740
  4. Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes. Taniguchi Y, et al. Am J Physiol Renal Physiol, 2012 May 1. PMID 22262481, Free PMC Article
  5. Cyclin I protects podocytes from apoptosis. Griffin SV, et al. J Biol Chem, 2006 Sep 22. PMID 16847066

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Subcellular localization of Cdk5 is determined by its specific activators, cyclin I and p35.
    Title: Cyclin I and p35 determine the subcellular distribution of Cdk5.
  2. Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
    Title: Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
  3. Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1).
    Title: Cyclin I protects podocytes from apoptosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420723.1 → NP_001407652.1  cyclin-I

    Status: VALIDATED

    Source sequence(s)
    AC134827
    UniProtKB/Swiss-Prot
    G3X985, Q9Z2V9

  2. NM_017367.4 → NP_059063.2  cyclin-I

    See identical proteins and their annotated locations for NP_059063.2

    Status: VALIDATED

    Source sequence(s)
    AC134827
    Consensus CDS
    CCDS19436.1
    UniProtKB/Swiss-Prot
    G3X985, Q9Z2V9
    UniProtKB/TrEMBL
    Q8C7E2, Q99LF2
    Related
    ENSMUSP00000050189.9, ENSMUST00000058550.15
    Conserved Domains (1) summary
    pfam00134
    Location:39 → 142
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    93329796..93354348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254086.2 → XP_030109946.1  cyclin-I isoform X2

    UniProtKB/TrEMBL
    Q8C7E2
    Conserved Domains (1) summary
    pfam00134
    Location:27 → 130
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2V9.4 GenPept UniProtKB/Swiss-Prot:Q9Z2V9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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