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Ccnf cyclin F [ Mus musculus (house mouse) ]

Gene ID: 12449, updated on 21-Apr-2024

Summary

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Official Symbol
Ccnfprovided by MGI
Official Full Name
cyclin Fprovided by MGI
Primary source
MGI:MGI:102551
See related
Ensembl:ENSMUSG00000072082 AllianceGenome:MGI:102551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CycF; Fbxo1
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction and centriole. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.32 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24441518..24470333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24223230..24251409, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene ATP-binding cassette, sub-family A member 17 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse cyclin F maps to a conserved linkage group on mouse chromosome 17. Obermayr F, et al. Mamm Genome, 1995 Feb. PMID 7767003
  2. Cyclin F disruption compromises placental development and affects normal cell cycle execution. Tetzlaff MT, et al. Mol Cell Biol, 2004 Mar. PMID 14993286, Free PMC Article
  3. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. Kong M, et al. EMBO J, 2000 Mar 15. PMID 10716937, Free PMC Article
  4. Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity. Yu Y, et al. Hum Mol Genet, 2019 Oct 15. PMID 31577344
  5. Identification of genes regulated by an interaction between alphavbeta3 integrin and vitronectin in murine decidua. Mangale SS, et al. Reprod Fertil Dev, 2008. PMID 18255021

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity
    Title: Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.
  2. SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity
    Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
  3. CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac and chorioallantoic placentation, die around embryonic day 10.5.
    Title: Cyclin F disruption compromises placental development and affects normal cell cycle execution.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of centrosome duplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within re-entry into mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-F
Names
G2/mitotic-specific cyclin-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409800.1 → NP_001396729.1  cyclin-F isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117577

  2. NM_001409801.1 → NP_001396730.1  cyclin-F isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117577

  3. NM_001409803.1 → NP_001396732.1  cyclin-F isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117577

  4. NM_001409804.1 → NP_001396733.1  cyclin-F isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC117577

  5. NM_001409805.1 → NP_001396734.1  cyclin-F isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC117577

  6. NM_001409806.1 → NP_001396735.1  cyclin-F isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC117577

  7. NM_001409807.1 → NP_001396736.1  cyclin-F isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117577

  8. NM_001409808.1 → NP_001396737.1  cyclin-F isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC117577

  9. NM_001409809.1 → NP_001396738.1  cyclin-F isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117577

  10. NM_001409832.1 → NP_001396761.1  cyclin-F isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC117577

  11. NM_007634.5 → NP_031660.3  cyclin-F isoform 4

    See identical proteins and their annotated locations for NP_031660.3

    Status: VALIDATED

    Source sequence(s)
    AC117577
    Consensus CDS
    CCDS37484.1
    UniProtKB/Swiss-Prot
    P51944, Q3TF73, Q60797, Q60799, Q8BSX9, Q8C4D9, Q8CI26
    Related
    ENSMUSP00000111048.4, ENSMUST00000115390.5
    Conserved Domains (3) summary
    smart00256
    Location:35 → 73
    FBOX; A Receptor for Ubiquitination Targets
    pfam00134
    Location:281 → 406
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:425 → 531
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24441518..24470333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51944.2 GenPept UniProtKB/Swiss-Prot:P51944

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