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Cbx2 chromobox 2 [ Mus musculus (house mouse) ]

Gene ID: 12416, updated on 12-Mar-2024

Summary

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Official Symbol
Cbx2provided by MGI
Official Full Name
chromobox 2provided by MGI
Primary source
MGI:MGI:88289
See related
Ensembl:ENSMUSG00000025577 AllianceGenome:MGI:88289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pc; M33; MOD2
Summary
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in results in male-to-female gonadal sex reversal. [provided by RefSeq, Sep 2015]
Expression
Broad expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Cbx2 in Genome Data Viewer
Location:
11 E2; 11 83.33 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118913845..118922101)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119023019..119031275)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35710 Neighboring gene STARR-positive B cell enhancer ABC_E10734 Neighboring gene STARR-seq mESC enhancer starr_31311 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 Neighboring gene predicted gene, 35829 Neighboring gene STARR-positive B cell enhancer ABC_E92 Neighboring gene chromobox 8 Neighboring gene predicted gene, 53657

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model. Hanka I, et al. Transpl Immunol, 2021 Aug. PMID 34033867
  2. Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements. Baumann C, et al. J Cell Biol, 2020 Nov 2. PMID 32870972, Free PMC Article
  3. Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2. Plys AJ, et al. Genes Dev, 2019 Jul 1. PMID 31171700, Free PMC Article
  4. Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation. Tatavosian R, et al. J Biol Chem, 2019 Feb 1. PMID 30514760, Free PMC Article
  5. Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones. Katoh-Fukui Y, et al. Bone, 2019 Mar. PMID 30389610

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice.
    Title: Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice.
  2. CBX2 in DSD: The Quirky Kid on the Block.
    Title: CBX2 in DSD: The Quirky Kid on the Block.
  3. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
    Title: Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis.
  4. Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
    Title: Role of CMV chemokine receptor M33 in airway graft rejection in a mouse transplant model.
  5. CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/beta-catenin pathway.
    Title: CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway.
  6. Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
    Title: Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements.
  7. This work identifies Cbx2 as a positive mediator in antiviral immunity, which provides new mechanistic insight into epigenetic modifiers in the innate immune response.
    Title: Polycomb chromobox Cbx2 enhances antiviral innate immunity by promoting Jmjd3-mediated demethylation of H3K27 at the Ifnb promoter.
  8. Cbx2 controls the maintenance and adipogenic differentiation of mesenchymal stromal cells in the bone marrow.
    Title: Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.
  9. The results suggest that stabilization of the testis fate requires CBX2-mediated repression of bivalent ovary-determining genes, which would otherwise block testis development.
    Title: CBX2 is required to stabilize the testis pathway by repressing Wnt signaling.
  10. Point mutations in an internal domain of Cbx2 eliminate phase separation and eliminate the formation of puncta in cells
    Title: Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in development of primary sexual characteristics ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromobox protein homolog 2
Names
M33 polycomb-like protein
chromobox homolog 2
modifier 3 protein
polycomb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007623.3 → NP_031649.2  chromobox protein homolog 2

    See identical proteins and their annotated locations for NP_031649.2

    Status: REVIEWED

    Source sequence(s)
    AK141647, BE986063, CJ176395, X62537
    Consensus CDS
    CCDS25708.1
    UniProtKB/Swiss-Prot
    A2ABG2, O35731, P30658, Q8CIA0
    UniProtKB/TrEMBL
    Q3TZG6
    Related
    ENSMUSP00000026662.8, ENSMUST00000026662.8
    Conserved Domains (1) summary
    pfam00385
    Location:15 → 61
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118913845..118922101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532104.1 → XP_006532167.1  chromobox protein homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3TZG6
    Conserved Domains (2) summary
    cd18647
    Location:9 → 61
    CD_Cbx2; chromodomain of chromobox homolog 2
    pfam17218
    Location:539 → 571
    CBX7_C; CBX family C-terminal motif

  2. XM_006532103.1 → XP_006532166.1  chromobox protein homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam17218
    Location:553 → 585
    CBX7_C; CBX family C-terminal motif

  3. XM_006532105.1 → XP_006532168.1  chromobox protein homolog 2 isoform X3

    Conserved Domains (1) summary
    pfam17218
    Location:492 → 524
    CBX7_C; CBX family C-terminal motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30658.2 GenPept UniProtKB/Swiss-Prot:P30658

Gene LinkOut

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