Cbr1 carbonyl reductase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbr1provided by MGI
Official Full Name: carbonyl reductase 1provided by MGI
Primary source: MGI:MGI:88284
See related: Ensembl:ENSMUSG00000051483 AllianceGenome:MGI:88284
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CR; Cbr; PG-9-KR
Summary: Predicted to enable carbonyl reductase (NADPH) activity and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Predicted to be involved in several processes, including phylloquinone catabolic process; prostaglandin catabolic process; and response to progesterone. Part of subapical complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human CBR1 (carbonyl reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 160.7), duodenum adult (RPKM 131.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 54.53 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (93404752..93407226)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (93607837..93610349)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Title: Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified.
Title: Carbonyl Reductase 1 Plays a Significant Role in Converting Doxorubicin to Cardiotoxic Doxorubicinol in Mouse Liver, but the Majority of the Doxorubicinol-Forming Activity Remains Unidentified.
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABAB receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
Title: Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA(B) receptor-dependent enhancement of synaptic inhibition in Down syndrome model mice.
These findings suggest that CBR1 generating 20beta-dihydrocortisol is a novel pathway modulating GR activation and providing enzymatic protection against excessive GR activation in obesity.
Title: Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
CBR1 plays a critical role in controlling redox balance and detoxifying lipid peroxidation during muscle differentiation and regeneration.
Title: Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration.
CBR1 attenuates apoptosis and promotes cell survival in pancreatic beta-cell lines under glucotoxic and glucolipotoxic conditions via reducing ROS generation
Title: Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129182 (e-PCR)
- UniSTS:212490

Cbr1 (e-PCR), detects polymorphism
- UniSTS:141248

AW261796 (e-PCR)
- UniSTS:180948

Cbr1 (e-PCR), detects polymorphism
- UniSTS:259049

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables carbonyl reductase (NADPH) activity	TAS Traceable Author Statement more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables prostaglandin-E2 9-reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucocorticoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucocorticoid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonyl reductase [NADPH] 1

Names: 15-hydroxyprostaglandin dehydrogenase; 20-beta-hydroxysteroid dehydrogenase; Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1); NADPH-dependent carbonyl reductase 1; alcohol dehydrogenase [NAD(P)+] CBR1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase

NP_031646.2

EC 1.1.1.184

EC 1.1.1.189

EC 1.1.1.196

EC 1.1.1.197

EC 1.1.1.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007620.3 → NP_031646.2 carbonyl reductase [NADPH] 1

See identical proteins and their annotated locations for NP_031646.2

Status: VALIDATED

Source sequence(s)

AC160993

Consensus CDS

CCDS28341.1

UniProtKB/Swiss-Prot

P48758, Q91X28

UniProtKB/TrEMBL

B2RXY7

Related

ENSMUSP00000049394.9, ENSMUST00000039659.9

Conserved Domains (2) summary

cd05324
Location:7 → 277

carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

pfam00106
Location:7 → 239

adh_short; short chain dehydrogenase