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NTAN1 N-terminal asparagine amidase [ Homo sapiens (human) ]

Gene ID: 123803, updated on 5-Mar-2024

Summary

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Official Symbol
NTAN1provided by HGNC
Official Full Name
N-terminal asparagine amidaseprovided by HGNC
Primary source
HGNC:HGNC:29909
See related
Ensembl:ENSG00000157045 MIM:615367; AllianceGenome:HGNC:29909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PNAA; PNAD
Summary
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in fat (RPKM 16.9), urinary bladder (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (15037857..15056074, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (15038909..15057126, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15131714..15149931, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene pyridoxal dependent decarboxylase domain containing 1 Neighboring gene KIAA2013 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:15106867-15106972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15109763-15110264 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:15110265-15110764 Neighboring gene microRNA 1972-1 Neighboring gene Sharpr-MPRA regulatory region 1947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15120969-15121592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15121593-15122216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:15122498-15123030 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:15149302-15149486 Neighboring gene MPRA-validated peak2507 silencer Neighboring gene RRN3 homolog, RNA polymerase I transcription factor Neighboring gene Sharpr-MPRA regulatory region 13846 Neighboring gene uncharacterized LOC100505915 Neighboring gene PKD1P6-NPIPP1 readthrough Neighboring gene nuclear pore complex interacting protein pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Ingason A, et al. Mol Psychiatry, 2011 Jan. PMID 19786961, Free PMC Article
  2. Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. Cantor JR, et al. Biochemistry, 2011 Apr 12. PMID 21375249, Free PMC Article
  3. Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. Kamdem LK, et al. Pharmacogenet Genomics, 2008 Jun. PMID 18496130
  4. Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling. Oh JH, et al. Proc Natl Acad Sci U S A, 2020 May 19. PMID 32366662, Free PMC Article
  5. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. Okada Y, et al. Hum Mol Genet, 2010 Jun 1. PMID 20189936

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that hNTAN1 is highly selective for the hydrolysis of N-terminal peptidyl L-Asn.
    Title: Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-09-17)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-09-17)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
EBI GWAS Catalog
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
EBI GWAS Catalog
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ54159, DKFZp666E058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-N-terminal asparagine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-N-terminal asparagine amidohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in memory IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein N-terminal asparagine amidohydrolase
Names
protein N-terminal Asn amidase
protein N-terminal asparagine amidase
protein NH2-terminal asparagine deamidase
protein NTN-amidase
NP_001257695.1
NP_001257696.1
NP_775745.1
XP_011520657.1
XP_047289543.1
XP_047289544.1
XP_054185028.1
XP_054235516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270766.2 → NP_001257695.1  protein N-terminal asparagine amidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_001257695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    BC017336, DC383993, HY036316
    Consensus CDS
    CCDS73832.1
    UniProtKB/TrEMBL
    A0A087X0T5
    Related
    ENSP00000485340.1, ENST00000624579.3
    Conserved Domains (1) summary
    pfam14736
    Location:1 → 199
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  2. NM_001270767.2 → NP_001257696.1  protein N-terminal asparagine amidohydrolase isoform 2

    See identical proteins and their annotated locations for NP_001257696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    BC017336, BF939373, HY036316
    Consensus CDS
    CCDS73832.1
    UniProtKB/TrEMBL
    A0A087X0T5
    Related
    ENSP00000483643.1, ENST00000622833.4
    Conserved Domains (1) summary
    pfam14736
    Location:1 → 199
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  3. NM_173474.4 → NP_775745.1  protein N-terminal asparagine amidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_775745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longesr transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC017336, HY036316
    Consensus CDS
    CCDS10558.1
    UniProtKB/Swiss-Prot
    Q7Z4Z0, Q96AB6
    Related
    ENSP00000287706.3, ENST00000287706.8
    Conserved Domains (1) summary
    pfam14736
    Location:39 → 304
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    15037857..15056074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433587.1 → XP_047289543.1  protein N-terminal asparagine amidohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A087X0T5

  2. XM_047433588.1 → XP_047289544.1  protein N-terminal asparagine amidohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A087X0T5

  3. XM_011522355.3 → XP_011520657.1  protein N-terminal asparagine amidohydrolase isoform X1

    See identical proteins and their annotated locations for XP_011520657.1

    Conserved Domains (1) summary
    pfam14736
    Location:36 → 221
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    613605..631830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329053.1 → XP_054185028.1  protein N-terminal asparagine amidohydrolase isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    15038909..15057126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379541.1 → XP_054235516.1  protein N-terminal asparagine amidohydrolase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AB6.3 GenPept UniProtKB/Swiss-Prot:Q96AB6

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