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Casp12 caspase 12 [ Mus musculus (house mouse) ]

Gene ID: 12364, updated on 14-Apr-2024

Summary

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Official Symbol
Casp12provided by MGI
Official Full Name
caspase 12provided by MGI
Primary source
MGI:MGI:1312922
See related
Ensembl:ENSMUSG00000025887 AllianceGenome:MGI:1312922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cysteine-type endopeptidase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and self proteolysis. Acts upstream of or within apoptotic process and endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.1), subcutaneous fat pad adult (RPKM 1.5) and 5 other tissues See more
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Genomic context

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Location:
9 A1; 9 2.46 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (5345419..5373034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (5345442..5373034)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53496 Neighboring gene STARR-positive B cell enhancer ABC_E10532 Neighboring gene caspase 1 Neighboring gene caspase 4, apoptosis-related cysteine peptidase Neighboring gene STARR-seq mESC enhancer starr_23174 Neighboring gene STARR-seq mESC enhancer starr_23175 Neighboring gene STARR-seq mESC enhancer starr_23176 Neighboring gene STARR-seq mESC enhancer starr_23177 Neighboring gene STARR-seq mESC enhancer starr_23178 Neighboring gene STARR-seq mESC enhancer starr_23179 Neighboring gene STARR-seq mESC enhancer starr_23180 Neighboring gene STARR-seq mESC enhancer starr_23181 Neighboring gene STARR-seq mESC enhancer starr_23183 Neighboring gene STARR-seq mESC enhancer starr_23184 Neighboring gene phosphoglucomutase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_23185 Neighboring gene STARR-seq mESC enhancer starr_23186 Neighboring gene STARR-seq mESC enhancer starr_23187 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis. Zhang X, et al. Int J Mol Sci, 2021 Jul 29. PMID 34360899, Free PMC Article
  2. Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis. Salvamoser R, et al. Cell Death Differ, 2019 Jun. PMID 30154447, Free PMC Article
  3. Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts. Song J, et al. J Cell Physiol, 2018 Dec. PMID 29943814
  4. Does caspase-12 suppress inflammasome activation? Vande Walle L, et al. Nature, 2016 Jun 2. PMID 27251234
  5. Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration. Bhootada Y, et al. Invest Ophthalmol Vis Sci, 2015 Jul. PMID 26207309, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis.
    Title: The Role of Caspase-12 in Retinal Bystander Cell Death and Innate Immune Responses against MCMV Retinitis.
  2. Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.
    Title: Inhibiting Caspase-12 Mediated Inflammasome Activation protects against Oxygen-Glucose Deprivation Injury in Primary Astrocytes.
  3. The caspase-12 does not have readily recognisable overlapping roles with caspases-1 and -11 in the inflammatory response induced by LPS and in necroptosis and apoptosis induced by diverse cytotoxic agents, including the ones that elicit ER stress.
    Title: Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis.
  4. caspase-12 cleavage at Asp94, induced by endoplasmic reticulum stress under mechanical stimuli, is the key molecule in initiating the stretch-triggered apoptosis of myoblasts.
    Title: Cleavage of caspase-12 at Asp94, mediated by endoplasmic reticulum stress (ERS), contributes to stretch-induced apoptosis of myoblasts.
  5. mice ablated for caspase-12 develop spontaneous obesity and insulin resistance.
    Title: Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
  6. Bnip3L and caspase-12 identified by the PCR arrays at both catagen stages were additionally localized using immunofluorescence and were reported in physiological hair development for the first time.
    Title: Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12.
  7. Caspase-12 plays a pivotal role in CCl4-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via caspase-9 activation.
    Title: Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice.
  8. We validated caspase-12 as a therapeutic target, ablation of which significantly protects T17M photoreceptors from deterioration.
    Title: Targeting Caspase-12 to Preserve Vision in Mice With Inherited Retinal Degeneration.
  9. Findings an increase in multiple unfolded protein response pathways in muscles of the dystrophin-deficient mdx mouse, the model for Duchenne muscular dystrophy.
    Title: Caspase-12 ablation preserves muscle function in the mdx mouse.
  10. Tauroursodeoxycholic acid intervention down-regulated GRP78 and CHOP expression and Caspase 12 activation.
    Title: The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of striated muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in self proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NLRP1 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
caspase-12
Names
CASP-12
NP_033938.3
XP_006509903.1
XP_036010474.1
XP_036010475.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009808.5 → NP_033938.3  caspase-12

    See identical proteins and their annotated locations for NP_033938.3

    Status: VALIDATED

    Source sequence(s)
    AC104914, AC141637
    Consensus CDS
    CCDS22800.1
    UniProtKB/Swiss-Prot
    O08736, Q3TT82
    UniProtKB/TrEMBL
    Q8BSX6
    Related
    ENSMUSP00000027009.5, ENSMUST00000027009.11
    Conserved Domains (2) summary
    smart00115
    Location:166 → 417
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:6 → 88
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    5345419..5373034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509840.3 → XP_006509903.1  caspase-12 isoform X3

    See identical proteins and their annotated locations for XP_006509903.1

    UniProtKB/TrEMBL
    E9Q575, Q6B837
    Related
    ENSMUSP00000122201.2, ENSMUST00000151332.2
    Conserved Domains (1) summary
    smart00115
    Location:96 → 347
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  2. XM_036154581.1 → XP_036010474.1  caspase-12 isoform X1

    UniProtKB/TrEMBL
    Q8BSX6
    Conserved Domains (2) summary
    smart00115
    Location:172 → 423
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:12 → 94
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

  3. XM_036154582.1 → XP_036010475.1  caspase-12 isoform X2

    UniProtKB/TrEMBL
    Q6B837
    Conserved Domains (1) summary
    smart00115
    Location:102 → 353
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08736.1 GenPept UniProtKB/Swiss-Prot:O08736

Gene LinkOut

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