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Car7 carbonic anhydrase 7 [ Mus musculus (house mouse) ]

Gene ID: 12354, updated on 21-Apr-2024

Summary

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Official Symbol
Car7provided by MGI
Official Full Name
carbonic anhydrase 7provided by MGI
Primary source
MGI:MGI:103100
See related
Ensembl:ENSMUSG00000031883 AllianceGenome:MGI:103100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca7
Summary
Enables carbonate dehydratase activity. Acts upstream of or within positive regulation of GABAergic synaptic transmission; positive regulation of cellular pH reduction; and regulation of chloride transport. Located in cytosol. Is expressed in several structures, including brain and genitourinary system. Orthologous to human CA7 (carbonic anhydrase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 10.1), cortex adult (RPKM 7.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105261326..105276979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104534694..104550347)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E6676 Neighboring gene STARR-positive B cell enhancer ABC_E2873 Neighboring gene STARR-seq mESC enhancer starr_22513 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1767 Neighboring gene STARR-seq mESC enhancer starr_22514 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density. Bertling E, et al. EMBO Rep, 2021 Apr 7. PMID 33719157, Free PMC Article
  2. The catalytic properties of murine carbonic anhydrase VII. Earnhardt JN, et al. Biochemistry, 1998 Jul 28. PMID 9692974
  3. Expression of mouse carbonic anhydrase VII in E. coli and demonstration of its CO2 hydrase activity. Lakkis MM, et al. Biochem Biophys Res Commun, 1996 Sep 4. PMID 8806625
  4. Annexin VII relocalization as a result of dystrophin deficiency. Selbert S, et al. Exp Cell Res, 1996 Jan 10. PMID 8549664
  5. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. Ruusuvuori E, et al. EMBO J, 2013 Aug 14. PMID 23881097, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
    Title: Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
  2. Car2, Car3, Car7, and Car15 mRNAs were barely within the detection limits in the mouse harderian gland.
    Title: Carbonic anhydrases in the mouse harderian gland.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cellular pH reduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carbonic anhydrase 7
Names
CA-VII
carbonate dehydratase VII
carbonic anhydrase VII
NP_001288093.1
NP_001288094.1
NP_001403595.1
NP_444300.1
XP_006530680.1
XP_006530681.1
XP_030099123.1
XP_036009627.1
XP_036009628.1
XP_036009629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301164.1 → NP_001288093.1  carbonic anhydrase 7 isoform b

    See identical proteins and their annotated locations for NP_001288093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC130543, BC094913, BY741075
    Consensus CDS
    CCDS80920.1
    UniProtKB/TrEMBL
    G3XA26, Q3UND9
    Related
    ENSMUSP00000125112.2, ENSMUST00000159416.8
    Conserved Domains (1) summary
    cl00012
    Location:1 → 206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. NM_001301165.1 → NP_001288094.1  carbonic anhydrase 7 isoform b

    See identical proteins and their annotated locations for NP_001288094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC130543, AK144275, BC094913
    Consensus CDS
    CCDS80920.1
    UniProtKB/TrEMBL
    G3XA26, Q3UND9
    Related
    ENSMUSP00000125404.2, ENSMUST00000162761.2
    Conserved Domains (1) summary
    cl00012
    Location:1 → 206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. NM_001416666.1 → NP_001403595.1  carbonic anhydrase 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC130543
    UniProtKB/TrEMBL
    G3XA26

  4. NM_053070.3 → NP_444300.1  carbonic anhydrase 7 isoform a

    See identical proteins and their annotated locations for NP_444300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (a).
    Source sequence(s)
    AC130543
    Consensus CDS
    CCDS22581.1
    UniProtKB/Swiss-Prot
    Q811X4, Q9ERQ8
    Related
    ENSMUSP00000052136.5, ENSMUST00000056051.11
    Conserved Domains (1) summary
    cd03149
    Location:27 → 262
    alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105261326..105276979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153734.1 → XP_036009627.1  carbonic anhydrase 7 isoform X2

    UniProtKB/TrEMBL
    Q3UND9
    Conserved Domains (1) summary
    cl00012
    Location:50 → 232
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. XM_030243263.2 → XP_030099123.1  carbonic anhydrase 7 isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:70 → 252
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. XM_036153735.1 → XP_036009628.1  carbonic anhydrase 7 isoform X4

    Conserved Domains (1) summary
    cl00012
    Location:2 → 158
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  4. XM_036153736.1 → XP_036009629.1  carbonic anhydrase 7 isoform X4

    Conserved Domains (1) summary
    cl00012
    Location:2 → 158
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  5. XM_006530617.4 → XP_006530680.1  carbonic anhydrase 7 isoform X3

    See identical proteins and their annotated locations for XP_006530680.1

    UniProtKB/TrEMBL
    G3XA26, Q3UND9
    Conserved Domains (1) summary
    cl00012
    Location:1 → 206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  6. XM_006530618.4 → XP_006530681.1  carbonic anhydrase 7 isoform X3

    See identical proteins and their annotated locations for XP_006530681.1

    UniProtKB/TrEMBL
    G3XA26, Q3UND9
    Conserved Domains (1) summary
    cl00012
    Location:1 → 206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERQ8.2 GenPept UniProtKB/Swiss-Prot:Q9ERQ8

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