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Capn7 calpain 7 [ Mus musculus (house mouse) ]

Gene ID: 12339, updated on 5-Mar-2024

Summary

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Official Symbol
Capn7provided by MGI
Official Full Name
calpain 7provided by MGI
Primary source
MGI:MGI:1338030
See related
Ensembl:ENSMUSG00000021893 AllianceGenome:MGI:1338030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PalBH
Summary
Predicted to enable MIT domain binding activity and endopeptidase activity. Involved in proteolysis. Predicted to be located in centrosome and cytosol. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human CAPN7 (calpain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 22.2), CNS E14 (RPKM 19.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.1 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31058582..31093944)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31336622..31371987)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Brca1 associated protein 1 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene STARR-positive B cell enhancer ABC_E10823 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32149566-32149675 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. Futai E, et al. Biochim Biophys Acta, 2001 Jan 26. PMID 11342116
  2. Capn7: a highly divergent vertebrate calpain with a novel C-terminal domain. Franz T, et al. Mamm Genome, 1999 Mar. PMID 10051333
  3. Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10. Yan Q, et al. Cell Death Dis, 2018 Feb 19. PMID 29459744, Free PMC Article
  4. Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus. Gafni J, et al. J Biol Chem, 2004 May 7. PMID 14981075
  5. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear TN, et al. Mech Dev, 1999 Dec. PMID 10559499

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of CAPN7 in Ishikawa cells or in the uterus of mice inhibited embryo implantation in vitro and in vivo.
    Title: Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10.
  2. calpain-derived Htt fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
    Title: Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MIT domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calpain-7
Names
palB homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360187.2 → NP_001347116.1  calpain-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108416
    Conserved Domains (3) summary
    smart00720
    Location:643 → 766
    calpain_III; calpain_III domain
    cd00044
    Location:170 → 494
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl00299
    Location:41 → 113
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  2. NM_001422190.1 → NP_001409119.1  calpain-7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108416

  3. NM_001422191.1 → NP_001409120.1  calpain-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416

  4. NM_001422192.1 → NP_001409121.1  calpain-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416

  5. NM_001422193.1 → NP_001409122.1  calpain-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416

  6. NM_001422194.1 → NP_001409123.1  calpain-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416

  7. NM_001422195.1 → NP_001409124.1  calpain-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108416

  8. NM_009796.4 → NP_033926.1  calpain-7 isoform 1

    See identical proteins and their annotated locations for NP_033926.1

    Status: VALIDATED

    Source sequence(s)
    AC108416
    Consensus CDS
    CCDS26911.1
    UniProtKB/Swiss-Prot
    Q9R1S8, Q9Z0P9
    Related
    ENSMUSP00000022451.8, ENSMUST00000022451.14
    Conserved Domains (4) summary
    smart00720
    Location:687 → 810
    calpain_III; calpain_III domain
    cd00044
    Location:214 → 538
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:5 → 76
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85 → 157
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

RNA

  1. NR_185495.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108416

  2. NR_185496.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108416

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31058582..31093944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158431.1 → XP_036014324.1  calpain-7 isoform X2

    Conserved Domains (4) summary
    smart00720
    Location:593 → 716
    calpain_III; calpain_III domain
    cd00044
    Location:214 → 538
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd02681
    Location:5 → 76
    MIT_calpain7_1; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in the nuclear thiol protease PalBH. The molecular function of the MIT domain is unclear.
    cl00299
    Location:85 → 157
    MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

  2. XM_036158430.1 → XP_036014323.1  calpain-7 isoform X1

    Conserved Domains (2) summary
    smart00720
    Location:522 → 645
    calpain_III; calpain_III domain
    cd00044
    Location:49 → 373
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1S8.1 GenPept UniProtKB/Swiss-Prot:Q9R1S8

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