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Pdia4 protein disulfide isomerase associated 4 [ Mus musculus (house mouse) ]

Gene ID: 12304, updated on 5-Mar-2024

Summary

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Official Symbol
Pdia4provided by MGI
Official Full Name
protein disulfide isomerase associated 4provided by MGI
Primary source
MGI:MGI:104864
See related
Ensembl:ENSMUSG00000025823 AllianceGenome:MGI:104864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cai; Erp72; ERp-72
Summary
Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in chaperone-mediated protein folding; positive regulation of protein folding; and response to endoplasmic reticulum stress. Located in cell surface and endoplasmic reticulum. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo; medulla oblongata basal plate; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human PDIA4 (protein disulfide isomerase family A member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 75.3), genital fat pad adult (RPKM 46.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Pdia4 in Genome Data Viewer
Location:
6 B2.3; 6 22.94 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47773075..47790446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47796141..47813512, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E438 Neighboring gene ribosomal protein L31, pseudogene 7 Neighboring gene RNA, Y1 small cytoplasmic, Ro-associated Neighboring gene microRNA 704 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:47763598-47763839 Neighboring gene ribosomal protein L35A, pseudogene 7 Neighboring gene zinc finger protein 786 Neighboring gene STARR-seq mESC enhancer starr_15785 Neighboring gene zinc finger protein 398

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy. Kuo TF, et al. EMBO Mol Med, 2021 Oct 7. PMID 34542937, Free PMC Article
  2. Functional characterization of 3 thioredoxin homology domains of ERp72. Satoh M, et al. Cell Stress Chaperones, 2005 Winter. PMID 16333982, Free PMC Article
  3. Protein degradation by ERp72 from rat and mouse liver endoplasmic reticulum. Urade R, et al. J Biol Chem, 1993 Oct 15. PMID 8408057
  4. Identification of genomic sequences that mediate the induction of the endoplasmic reticulum stress protein, ERp72, by protein traffic. Srinivasan M, et al. DNA Cell Biol, 1993 Nov. PMID 8216852
  5. An mRNA sharing sequences with a variant granulocyte-macrophage colony stimulating factor cDNA clone. Gough NM, et al. Nucleic Acids Res, 1987 Dec 23. PMID 3320970, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
    Title: Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity to Influence Neutrophil Recruitment.
  2. PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue.
    Title: PDIA4, a novel ER stress chaperone, modulates adiponectin expression and inflammation in adipose tissue.
  3. Pdia4 regulates beta-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
    Title: Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
  4. activated by IL11 in placenta
    Title: Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice.
  5. PDIA4 as a negative regulator of cancer cell apoptosis.
    Title: Protein disulfide isomerase a4 acts as a novel regulator of cancer growth through the procaspase pathway.
  6. ERp72 functions separately from protein disulfide isomerase and ERp57 in supporting platelet aggregation. Defective aggregation of ERp72-null platelets was recovered by ERp72, but not other thiol isomerases.
    Title: The disulfide isomerase ERp72 supports arterial thrombosis in mice.
  7. A network of endoplasmic reticulum ERp57, ERp72, and ERp29 facilitate polyomavirus infection.
    Title: A PDI family network acts distinctly and coordinately with ERp29 to facilitate polyomavirus infection.
  8. There were increased numbers of ERp72-immunoreactive cells in the dorsal and lateral cortex during sleep deprivation.
    Title: Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep.
  9. These results suggest that domains 1 and 2 of ERp72 contribute to catalytic efficacy, and domain 3 to binding affinity.
    Title: Functional characterization of 3 thioredoxin homology domains of ERp72.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-disulfide reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein disulfide-isomerase A4
Names
ER protein 72
calcium binding protein, intestinal
endoplasmic reticulum protein 72
endoplasmic reticulum resident protein 72
NP_001355685.1
NP_033917.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368756.1 → NP_001355685.1  protein disulfide-isomerase A4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC166252
    UniProtKB/Swiss-Prot
    P08003, P15841, Q3TT79, Q3UJW0, Q6NXW4, Q8BMT8
    Conserved Domains (2) summary
    TIGR01126
    Location:63 → 164
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:173 → 691
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. NM_009787.2 → NP_033917.2  protein disulfide-isomerase A4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_033917.2

    Status: VALIDATED

    Source sequence(s)
    AK161534, BC066857, CF165880
    Consensus CDS
    CCDS20097.1
    UniProtKB/Swiss-Prot
    P08003, P15841, Q3TT79, Q3UJW0, Q6NXW4, Q8BMT8
    UniProtKB/TrEMBL
    A0A0R4J0Z1
    Related
    ENSMUSP00000076521.8, ENSMUST00000077290.9
    Conserved Domains (5) summary
    cd02995
    Location:522 → 627
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    cd03068
    Location:282 → 388
    PDI_b_ERp72; PDIb family, ERp72 subfamily, first redox inactive TRX-like domain b; ERp72 exhibits both disulfide oxidase and reductase functions like PDI, by catalyzing the formation of disulfide bonds of newly synthesized polypeptides in the ER and acting as ...
    cd03073
    Location:393 → 502
    PDI_b'_ERp72_ERp57; PDIb' family, ERp72 and ERp57 subfamily, second redox inactive TRX-like domain b'; ERp72 and ER57 are involved in oxidative protein folding in the ER, like PDI. They exhibit both disulfide oxidase and reductase functions, by catalyzing the formation of ...
    TIGR01126
    Location:178 → 279
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:173 → 633
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47773075..47790446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08003.3 GenPept UniProtKB/Swiss-Prot:P08003

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