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Cacna2d3 calcium channel, voltage-dependent, alpha2/delta subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 12294, updated on 21-Apr-2024

Summary

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Official Symbol
Cacna2d3provided by MGI
Official Full Name
calcium channel, voltage-dependent, alpha2/delta subunit 3provided by MGI
Primary source
MGI:MGI:1338890
See related
Ensembl:ENSMUSG00000021991 AllianceGenome:MGI:1338890
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cacnad3; alapha2delta3
Summary
Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 15.3), CNS E18 (RPKM 9.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A3; 14 16.8 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (28626900..29444732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (28904943..29722775, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 pseudogene Neighboring gene predicted gene, 35217 Neighboring gene STARR-seq mESC enhancer starr_36285 Neighboring gene leucine-rich repeats and transmembrane domains 1 Neighboring gene STARR-seq mESC enhancer starr_36286 Neighboring gene peptidylprolyl isomerase A pseudogene 15 Neighboring gene STARR-seq mESC enhancer starr_36287 Neighboring gene STARR-seq mESC enhancer starr_36288 Neighboring gene STARR-seq mESC enhancer starr_36289 Neighboring gene STARR-seq mESC enhancer starr_36290 Neighboring gene STARR-seq mESC enhancer starr_36291 Neighboring gene predicted gene, 41118 Neighboring gene predicted gene, 57619 Neighboring gene predicted gene, 35281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. α(2)δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions. Ablinger C, et al. Int J Mol Sci, 2022 Aug 31. PMID 36077281, Free PMC Article
  2. Impaired Subcortical Processing of Amplitude-Modulated Tones in Mice Deficient for Cacna2d3, a Risk Gene for Autism Spectrum Disorders in Humans. Bracic G, et al. eNeuro, 2022 Mar-Apr. PMID 35410870, Free PMC Article
  3. Role of α2δ3 in Cellular Synchronization of the Suprachiasmatic Nucleus Under Constant Light Conditions. Matsuo M, et al. Neuroscience, 2021 May 1. PMID 33609639
  4. Deletion of the Ca(2+) Channel Subunit α(2)δ3 Differentially Affects Ca(v)2.1 and Ca(v)2.2 Currents in Cultured Spiral Ganglion Neurons Before and After the Onset of Hearing. Stephani F, et al. Front Cell Neurosci, 2019. PMID 31293392, Free PMC Article
  5. Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice. Landmann J, et al. Brain Struct Funct, 2018 Jan. PMID 28733833

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
    Title: Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
  2. Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice.
    Title: Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice.
  3. Presynaptic alpha2delta subunits are key organizers of glutamatergic synapses.
    Title: Presynaptic α(2)δ subunits are key organizers of glutamatergic synapses.
  4. The data of this study demonstrate that knock out of CACN alpha2delta3 results in some structural abnormalities whose functional implications converge to dedifferentiation of sensory activation.
    Title: Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice.
  5. our results identify a novel role for the alpha2delta3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.
    Title: α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders.
  6. Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) exhibit impaired behavioral heat pain sensitivity.
    Title: A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-3
Names
alpha 2 delta-3
voltage-dependent calcium channel alpha2/delta-3 transcript
voltage-gated calcium channel subunit alpha-2/delta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009785.1 → NP_033915.1  voltage-dependent calcium channel subunit alpha-2/delta-3 precursor

    See identical proteins and their annotated locations for NP_033915.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ010949
    UniProtKB/Swiss-Prot
    Q9Z1L5
    UniProtKB/TrEMBL
    A0A411ACY3
    Related
    ENSMUSP00000022567.8, ENSMUST00000022567.9
    Conserved Domains (4) summary
    cd01463
    Location:242 → 425
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    pfam02743
    Location:452 → 548
    Cache_1; Cache domain
    pfam08399
    Location:113 → 229
    VWA_N; VWA N-terminal
    pfam08473
    Location:561 → 633
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    28626900..29444732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158421.1 → XP_036014314.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3

    Conserved Domains (5) summary
    cd01463
    Location:242 → 395
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    cd12912
    Location:472 → 586
    PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains
    cl38916
    Location:416 → 470
    HK_sensor; Sensor domains of Histidine Kinase receptors
    pfam08399
    Location:113 → 229
    VWA_N; VWA N-terminal
    pfam08473
    Location:619 → 1032
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

  2. XM_011244938.4 → XP_011243240.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2

    Conserved Domains (5) summary
    cd01463
    Location:242 → 395
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    cd12912
    Location:478 → 592
    PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains
    pfam08399
    Location:113 → 229
    VWA_N; VWA N-terminal
    pfam08473
    Location:625 → 1038
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    pfam02743
    Location:412 → 522
    dCache_1; Cache domain

  3. XM_006518486.5 → XP_006518549.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1

    Conserved Domains (5) summary
    cd01463
    Location:242 → 425
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    cd12912
    Location:502 → 616
    PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains
    pfam08399
    Location:113 → 229
    VWA_N; VWA N-terminal
    pfam08473
    Location:649 → 1062
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    pfam02743
    Location:442 → 546
    dCache_1; Cache domain

  4. XM_030247616.2 → XP_030103476.1  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X4

    Conserved Domains (5) summary
    cd01463
    Location:148 → 331
    vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
    cd12912
    Location:414 → 528
    PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains
    pfam08399
    Location:19 → 135
    VWA_N; VWA N-terminal
    pfam08473
    Location:561 → 974
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    pfam02743
    Location:348 → 458
    dCache_1; Cache domain

RNA

  1. XR_001781093.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1L5.1 GenPept UniProtKB/Swiss-Prot:Q9Z1L5

Gene LinkOut

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