Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1dprovided by MGI
Official Full Name: calcium channel, voltage-dependent, L type, alpha 1D subunitprovided by MGI
Primary source: MGI:MGI:88293
See related: Ensembl:ENSMUSG00000015968 AllianceGenome:MGI:88293
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cach3; Cacn4; Cav1.3; Cchl1a; D-LTCC; Cchl1a2; Cacnl1a2; 8430418G19Rik
Summary: This gene encodes a pore-forming subunit of the L-type, voltage-activated calcium channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Expression: Broad expression in frontal lobe adult (RPKM 8.2), CNS E18 (RPKM 6.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3- B; 14 18.43 cM

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (29761898..30213113, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (30039941..30491156, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of CaV1.3 L-type calcium channels in a mouse model of retinitis pigmentosa.
Title: Knockout of Ca(V)1.3 L-type calcium channels in a mouse model of retinitis pigmentosa.
Concomitant genetic ablation of L-type Cav1.3 (alpha1D) and T-type Cav3.1 (alpha1G) Ca(2+) channels disrupts heart automaticity.
Title: Concomitant genetic ablation of L-type Ca(v)1.3 (α(1D)) and T-type Ca(v)3.1 (α(1G)) Ca(2+) channels disrupts heart automaticity.
Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness.
Title: Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness.
Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice.
Title: Down-regulation of Cav1.3 in auditory pathway promotes age-related hearing loss by enhancing calcium-mediated oxidative stress in male mice.
Cav1.3 knockout pups exhibited delayed bone mineral accrual, compensatory nifedipine-insensitive Ca(2+) absorption in the ileum, and increased expression of renal Ca(2+) reabsorption mediators at P14. Moreover, weaning pups at 2 weeks reduced jejunal and ileal Cav1.3 expression. C
Title: TRPV6 and Ca(v)1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning.
Data show that editing of Cav1.3 calcium channel (CaV1.3) was potently inhibited by serine/arginine-rich splicing factor 9 (SRSF9).
Title: Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9.
The molecular interactions engaging D4 in VSD IV contribute to voltage-sensing in all examined CaV1.3 channel, however its striking role in regulating the gating properties by alternative splicing appears to be a unique property of the skeletal muscle CaV1.1 channel.
Title: Role of putative voltage-sensor countercharge D4 in regulating gating properties of Ca(V)1.2 and Ca(V)1.3 calcium channels.
This study showed that Cav1.3 channels promote type-1 cell proliferation, neuronal fate choice, and subsequent neuronal differentiation. Cav1.3 channels expressed on type-1 cells
Title: Type-1 astrocyte-like stem cells harboring Cacna1d gene deletion exhibit reduced proliferation and decreased neuronal fate choice.
The results signify a developmental decline in the sensitivity of CDI to global elevations in Ca ( 2+) , which restricts negative feedback regulation of Cav 1.3 channels to incoming Ca ( 2+) ions in mature inner hair cells (IHCs).
Title: Developmental alterations in the biophysical properties of Ca(v) 1.3 Ca(2+) channels in mouse inner hair cells.
Ventral tegmental area Cav1.3 channel activation robustly mediates cocaine-related, depression-related and social behavior via distinct nucleus accumbens AMPAR mechanisms with no effect on anxiety-like behavior.
Title: Enhancing VTA Ca(v)1.3 L-type Ca(2+) channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14Mit127 (e-PCR), detects polymorphism
- UniSTS:127232

Cacna1d (e-PCR), detects polymorphism
- UniSTS:461906

Cacna1d (e-PCR), detects polymorphism
- UniSTS:461907

Cacna1d (e-PCR), detects polymorphism
- UniSTS:461908

AW530962 (e-PCR)
- UniSTS:244577

RH126634 (e-PCR)
- UniSTS:209009

AU041472 (e-PCR)
- UniSTS:180621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved SA node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity involved SA node cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels	TAS Traceable Author Statement more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane depolarization during SA node cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization during SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of heart rate by cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cochlear hair cell ribbon synapse	IC Inferred by Curator more info	PubMed
is_active_in cochlear hair cell ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cochlear hair cell ribbon synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in primary dendrite	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit alpha-1D

Names: Cav1.3alpha1; alpha 1 E; calcium channel, L type, alpha-1 polypeptide; voltage-gated calcium channel subunit alpha Cav1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083616.2 → NP_001077085.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.

Source sequence(s)

AJ437291, AK032552, AK147415, BP761485

Consensus CDS

CCDS36847.1

UniProtKB/TrEMBL

A0A2C9F2E5

Related

ENSMUSP00000153250.3, ENSMUST00000224198.3

Conserved Domains (4) summary

pfam00520
Location:1222 → 1460

Ion_trans; Ion transport protein

pfam08763
Location:1533 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1628 → 2141

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1468 → 1531

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001302637.1 → NP_001289566.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform 3

See identical proteins and their annotated locations for NP_001289566.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AJ437291, AK032552, AK147415, BP761485

Consensus CDS

CCDS88609.1

UniProtKB/Swiss-Prot

Q7TSD2, Q8R2I9, Q8R2J0, Q99246

UniProtKB/TrEMBL

A0A2C9F2E5

Related

ENSMUSP00000158632.2, ENSMUST00000238504.2

Conserved Domains (4) summary

pfam00520
Location:1242 → 1495

Ion_trans; Ion transport protein

pfam08763
Location:1568 → 1639

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1663 → 2176

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1503 → 1566

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_028981.3 → NP_083257.2 voltage-dependent L-type calcium channel subunit alpha-1D isoform 1

See identical proteins and their annotated locations for NP_083257.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and has multiple coding region differences, compared to variant 3. These differences cause translation initiation at an alternate start codon, compared to variant 3. This results in a distinct N-terminus and shorter protein (isoform 1), compared to isoform 3.

Source sequence(s)

AJ437291, AJ437292, AK032552, AK147415, BP761485

Consensus CDS

CCDS36846.1

UniProtKB/TrEMBL

A0A2C9F2E5

Related

ENSMUSP00000107869.4, ENSMUST00000112250.6

Conserved Domains (4) summary

pfam00520
Location:1244 → 1482

Ion_trans; Ion transport protein

pfam08763
Location:1555 → 1626

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1650 → 2163

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1490 → 1553

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

29761898..30213113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315824.3 → XP_017171313.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X23

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1533 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1627 → 2143

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1469 → 1522

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315823.3 → XP_017171312.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X22

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1561 → 1632

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1655 → 2171

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1497 → 1550

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315811.3 → XP_017171300.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1576 → 1647

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1670 → 2186

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1512 → 1565

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036158415.1 → XP_036014308.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1595 → 1666

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1689 → 2203

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1531 → 1584

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315819.3 → XP_017171308.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1525 → 1596

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1619 → 2135

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1461 → 1514

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315817.3 → XP_017171306.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1540 → 1611

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1634 → 2150

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1476 → 1529

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315815.3 → XP_017171304.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1553 → 1624

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1647 → 2163

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1489 → 1542

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315813.3 → XP_017171302.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1568 → 1639

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1662 → 2178

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1504 → 1557

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315816.3 → XP_017171305.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1553 → 1624

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1647 → 2163

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1489 → 1542

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315810.3 → XP_017171299.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1581 → 1652

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1675 → 2191

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1517 → 1570

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036158416.1 → XP_036014309.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1596 → 1667

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1690 → 2145

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315809.3 → XP_017171298.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1596 → 1667

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1690 → 2197

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006518475.3 → XP_006518538.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1596 → 1667

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1690 → 2206

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315825.3 → XP_017171314.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X24

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1533 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1627 → 2143

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1469 → 1522

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006518480.3 → XP_006518543.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

UniProtKB/TrEMBL

A0A2C9F2E5, A0A589Q4M7

Related

ENSMUSP00000153586.3, ENSMUST00000223803.3

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1533 → 1604

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1627 → 2134

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1469 → 1522

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006518479.3 → XP_006518542.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

UniProtKB/TrEMBL

A0A286YD72, A0A2C9F2E5

Related

ENSMUSP00000153293.3, ENSMUST00000224785.3

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1548 → 1619

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1642 → 2158

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1484 → 1537

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315812.3 → XP_017171301.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1576 → 1647

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1670 → 2186

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1512 → 1565

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315814.3 → XP_017171303.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1568 → 1639

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1662 → 2178

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1504 → 1557

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315808.3 → XP_017171297.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1596 → 1667

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1690 → 2206

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315818.3 → XP_017171307.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:57 → 349

Ion_trans; Ion transport protein

pfam08763
Location:1528 → 1599

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1622 → 2138

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1464 → 1517

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036158417.1 → XP_036014310.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

UniProtKB/TrEMBL

A0A2C9F2E5

Conserved Domains (4) summary

pfam00520
Location:820 → 1119

Ion_trans; Ion transport protein

pfam08763
Location:1192 → 1263

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1286 → 1800

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1128 → 1181

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017315820.3 → XP_017171309.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

UniProtKB/TrEMBL

A0A571BDT1

Conserved Domains (3) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl26695
Location:1596 → 1647

Ca_chan_IQ; Voltage gated calcium channel IQ domain
XM_017315821.3 → XP_017171310.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

UniProtKB/TrEMBL

A0A571BDT1

Related

ENSMUSP00000158773.2, ENSMUST00000238568.2

Conserved Domains (3) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein

pfam08763
Location:1596 → 1667

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16905
Location:1532 → 1585

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036158419.1 → XP_036014312.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

Conserved Domains (1) summary

pfam00520
Location:125 → 417

Ion_trans; Ion transport protein