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Hyou1 hypoxia up-regulated 1 [ Mus musculus (house mouse) ]

Gene ID: 12282, updated on 21-Apr-2024

Summary

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Official Symbol
Hyou1provided by MGI
Official Full Name
hypoxia up-regulated 1provided by MGI
Primary source
MGI:MGI:108030
See related
Ensembl:ENSMUSG00000032115 AllianceGenome:MGI:108030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cab140; Grp170; Orp150; CBP-140
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway and response to ischemia. Part of endoplasmic reticulum chaperone complex. Is expressed in embryo and tail. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 39.8), placenta adult (RPKM 37.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44290840..44303662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44379490..44392369)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40516 Neighboring gene predicted gene 10080 Neighboring gene STARR-positive B cell enhancer ABC_E1785 Neighboring gene STARR-positive B cell enhancer ABC_E5063 Neighboring gene predicted gene, 26306 Neighboring gene solute carrier family 37 (glucose-6-phosphate transporter), member 4 Neighboring gene microRNA 7085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice. Porter AW, et al. JCI Insight, 2022 Mar 8. PMID 35104250, Free PMC Article
  2. Coordination of Grp1 recruitment mechanisms by its phosphorylation. Li J, et al. Mol Biol Cell, 2020 Dec 1. PMID 33026967, Free PMC Article
  3. Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice. Tanaka K, et al. Biochem Biophys Res Commun, 2012 Sep 7. PMID 22892132
  4. Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity. Zuo D, et al. FASEB J, 2012 Apr. PMID 22207611, Free PMC Article
  5. Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo. Arnouk H, et al. Int J Hyperthermia, 2010. PMID 20210603, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
    Title: Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function.
  2. FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
    Title: FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
  3. The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
    Title: The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice.
  4. Coordination of Grp1 recruitment mechanisms by its phosphorylation.
    Title: Coordination of Grp1 recruitment mechanisms by its phosphorylation.
  5. The protein but not the mRNA level of ORP150, a nucleotide exchange factor which can substitute for SIL1, was increased in the cerebellum of GSK2606414-treated woozy mice, suggesting that translational recovery promoted the synthesis of this alternative BiP co-factor
    Title: PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
  6. The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions
    Title: Hypoxia mediates osteocyte ORP150 expression and cell death in vitro.
  7. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.
    Title: The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s.
  8. These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 and myofibroblasts.
    Title: Expression of 150-kDa oxygen-regulated protein (ORP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice.
  9. Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 activation on pathogen recognition.
    Title: Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity.
  10. AICAR infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis
    Title: Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to ischemia IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ischemia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hypoxia up-regulated protein 1
Names
140 kDa Ca(2+)-binding protein
150-kDa oxygen regulated protein
170 kDa glucose regulated protein GRP170
GRP-170
calcium binding protein 140
calcium binding protein, 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411630.1 → NP_001398559.1  hypoxia up-regulated protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122428

  2. NM_001411631.1 → NP_001398560.1  hypoxia up-regulated protein 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC122428

  3. NM_021395.5 → NP_067370.3  hypoxia up-regulated protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067370.3

    Status: VALIDATED

    Source sequence(s)
    AC122428
    Consensus CDS
    CCDS23107.1
    UniProtKB/Swiss-Prot
    Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
    Related
    ENSMUSP00000068594.7, ENSMUST00000066601.13
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586 → 691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554 → 767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44290840..44303662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509960.4 → XP_006510023.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510023.1

    UniProtKB/Swiss-Prot
    Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
    Related
    ENSMUSP00000123700.2, ENSMUST00000161318.8
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586 → 691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554 → 767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  2. XM_006509961.4 → XP_006510024.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510024.1

    UniProtKB/Swiss-Prot
    Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586 → 691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554 → 767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  3. XM_006509959.4 → XP_006510022.1  hypoxia up-regulated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006510022.1

    UniProtKB/Swiss-Prot
    Q3TAL1, Q3TZD0, Q3U1U2, Q64139, Q80X75, Q9JKR6
    Related
    ENSMUSP00000125594.2, ENSMUST00000160902.8
    Conserved Domains (3) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA03169
    Location:586 → 691
    PHA03169; hypothetical protein; Provisional
    COG5271
    Location:554 → 767
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

  4. XM_006509962.4 → XP_006510025.1  hypoxia up-regulated protein 1 isoform X2

    Conserved Domains (2) summary
    cd10230
    Location:36 → 424
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    PHA00666
    Location:597 → 760
    PHA00666; putative protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKR6.1 GenPept UniProtKB/Swiss-Prot:Q9JKR6

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